How to cite this article: Shanjani Y, Hu Y, Toyserkani E, Grynpas M, Kandel RA, Pilliar RM. 2013. Solid freeform fabrication of porous calcium polyphosphate structures for bone substitute applications: In vivo studies. J Biomed Mater Res Part B 2013:101B:972–980.
Solid freeform fabrication of porous calcium polyphosphate structures for bone substitute applications: In vivo studies†
Article first published online: 26 MAR 2013
Copyright © 2013 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 101B, Issue 6, pages 972–980, August 2013
How to Cite
Shanjani, Y., Hu, Y., Toyserkani, E., Grynpas, M., Kandel, R. A. and Pilliar, R. M. (2013), Solid freeform fabrication of porous calcium polyphosphate structures for bone substitute applications: In vivo studies. J. Biomed. Mater. Res., 101B: 972–980. doi: 10.1002/jbm.b.32905
- Issue published online: 12 JUL 2013
- Article first published online: 26 MAR 2013
- Manuscript Accepted: 17 JAN 2013
- Manuscript Revised: 16 JAN 2013
- Manuscript Received: 3 DEC 2012
- Natural Sciences and Engineering Council of Canada and the U.S. Army Medical Research and Materiel Command #W81XWH-10-1-0786
- solid freeform fabrication;
- porous calcium polyphosphate;
- bone ingrowth;
- bone substitute;
- rabbit model study
Porous calcium polyphosphate (CPP) structures with 30 volume percent porosity and made by solid freeform fabrication (SFF) were implanted in rabbit femoral condyle sites for 6-wk periods. Two forms of SFF implants with different stacked layer orientation were made in view of prior studies reporting on anisotropic/orthotropic mechanical properties of structures so formed. In addition, porous CPP implants of equal volume percent porosity made by conventional sintering and machining methods were prepared. Bone ingrowth and in vivo degradation of the three different implant types were compared using back-scattered scanning electron microscopy (BS-SEM) of implant samples and quantitative analysis of the images. The results indicated bone ingrowth with all samples resulting in 30–40% fill of available porosity by bone within the 6-wk period. In the 6-wk in vivo period, approximately 7–9% loss of CPP by degradation had occurred. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.