How to cite this article: Chung C-J, Su R-T, Chu H-J, Chen H-T, Tsou H-K, He J-L. 2013. Plasma electrolytic oxidation of titanium and improvement in osseointegration. J Biomed Mater Res Part B 2013:101B:1023–1030.
Plasma electrolytic oxidation of titanium and improvement in osseointegration†
Article first published online: 26 MAR 2013
Copyright © 2013 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 101B, Issue 6, pages 1023–1030, August 2013
How to Cite
Chung, C.-J., Su, R.-T., Chu, H.-J., Chen, H.-T., Tsou, H.-K. and He, J.-L. (2013), Plasma electrolytic oxidation of titanium and improvement in osseointegration. J. Biomed. Mater. Res., 101B: 1023–1030. doi: 10.1002/jbm.b.32912
- Issue published online: 12 JUL 2013
- Article first published online: 26 MAR 2013
- Manuscript Accepted: 30 JAN 2013
- Manuscript Revised: 16 JAN 2013
- Manuscript Received: 21 SEP 2012
- National Science Council of the Republic of China, Taiwan. Grant Numbers: NSC 98–2218–E–166–001, NSC 98–2622–8–035–003–A1, NSC 99–2221–E–166–001, NSC 100–2221–E–166–006
- plasma electrolytic oxidation (PEO);
- titanium dioxide (TiO2);
- hydroxyapatite (HAp);
- strontium-containing hydroxyapatite (Sr-HAp);
- dual-phase HAp-TiO2;
Reducing the osseointegration time for biomedical titanium implants in surgical patients is an important goal. However, a huge controversy exists over the effectiveness of osseointegration of the surface layer by plasma electrolytic oxidation (PEO), which is a widely favored surface modification for titanium-based implants. In this study, various surface coatings, including anatase-TiO2 (A-TiO2), rutile-TiO2 (R-TiO2), hydroxyapatite (HAp), strontium-containing hydroxyapatite (Sr-HAp), and dual-phase HAp-TiO2 were synthesized on titanium implants by PEO. A comparative study of osseointegration performance (both in vitro and in vivo) and bone/implant adhesion strength conducted using push-out thrust tests were demonstrated. The in vitro experimental test results agree strongly with the in vivo test results: the dual-phase HAp-TiO2 coating exhibits the superior cell adhesion and differentiation condition among all of the coatings in the in vitro tests and therefore has the highest push-out bonding strength of 5.37 MPa after 12 wk of implantation in the in vivo test. The HAp-containing coatings benefit from its bioactivity and therefore perform the others in terms of long-term osteocyte growth (from the in vitro results) and the extent of osseointegration (from the in vivo results). The dual-phase HAp-TiO2 coating provides the advantages of both the bioactive HAp and structural enhancement by the TiO2, effectively promoting osseointegration. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.