Original Research Report
Multilayer scaffold of electrospun PLA–PCL–collagen nanofibers as a dural substitute
Version of Record online: 17 MAY 2013
Copyright © 2013 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 101, Issue 8, pages 1359–1366, November 2013
How to Cite
How to cite this article: 2013. Multilayer scaffold of electrospun PLA–PCL–collagen nanofibers as a dural substitute. J Biomed Mater Res Part B 2013:101B:1359–1366., , .
- Issue online: 22 OCT 2013
- Version of Record online: 17 MAY 2013
- Manuscript Accepted: 27 MAR 2013
- Manuscript Revised: 15 MAR 2013
- Manuscript Received: 22 AUG 2012
- dural substitutes;
- poly-lactic acid;
Dural closure after the neurosurgery can prevent postoperative complications. Although many types of dural substitute have been developed, most of them lack functional and structural characteristics compared with the natural dura mater. In this study, we used electrospinning method to fabricate a multilayer scaffold to promote dural repair. The inner layer of the scaffold that faces the brain tissue is composed of poly-lactic acid (PLA) to reduce tissue adhesion. The middle layer of the scaffold is composed of poly-ɛ-caprolactone and PLA, which provides a watertight seal. The outer layer of the scaffold contains a large amount of collagen to promote cell attachment and proliferation. The results from in vitro study and an animal model have shown that this multilayer fibrous scaffold has sufficient mechanic strength and biochemical properties to enhance dural repair. Therefore, fabrication of scaffold with multiple functional and structural layers may provide a novel approach for tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 101B: 1359–1366, 2013.