Antibacterial property expressed by a novel calcium phosphate glass
Article first published online: 11 SEP 2013
Copyright © 2013 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 102, Issue 3, pages 423–429, April 2014
How to Cite
How to cite this article: 2014. Antibacterial property expressed by a novel calcium phosphate glass. J Biomed Mater Res Part B 2014: 102B: 423–429., , , , .
- Issue published online: 6 MAR 2014
- Article first published online: 11 SEP 2013
- Manuscript Accepted: 10 AUG 2013
- Manuscript Revised: 3 JUN 2013
- Manuscript Received: 22 FEB 2013
- NIH/NIDCR. Grant Number: 2R01 DE017925 (to PIZ)
- NSF. Grant Number: CMMI-0758530 (to PIZ)
- NIH/NIAMS. Grant Number: R01 AR056208 (to PIL/YZ)
- NIH/NIDCR. Grant Number: DE019178 (to PIS)
- NIH/NIDCR. Grant Number: DE020891 (to PIS)
- calcium phosphate glass;
- antimicrobial properties;
- Streptococcus mutans;
We have developed a calcium phosphate glass (CPG) doped with Zn2+ or F− or combined Zn2+ and F− ions, which are naturally found in the human body and play a dual role in bone formation and antibacterial activity. Previously, we have demonstrated that this family of CPGs has superior osteoconductive and resorbable properties in vivo. This study aimed to investigate the antibacterial property of CPGs incorporating Zn2+ and/or F−. We used Streptococcus mutans as a model organism because it is one of the major human oral pathogens and an early colonizer, and it has been associated with several oral infections, such as dental caries, periodontitis, and peri-implantitis. CPGs of 0.01 and 0.05 g were incubated with S. mutans for 0, 2, 4, and 6 h. Serial dilutions were plated in triplicate and colony forming units were determined. The antimicrobial effect of CPG incorporating Zn2+ or F− was greater than CPG incorporating both these ions. CPG without doping produced a moderate antimicrobial effect. This family of CPGs, previously shown to promote new bone formation in vivo, is demonstrated to have superior bactericidal properties. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 423–429, 2014.