Part of this study was presented at the 31st Annual Meeting of the ASBMR, in Denver, CO, USA, on (September 13, 2009).
Original Article
You have full text access to this OnlineOpen article
Fracture risk prediction using BMD and clinical risk factors in early postmenopausal women: Sensitivity of the WHO FRAX tool†
Article first published online: 8 JAN 2010
DOI: 10.1002/jbmr.12
Copyright © 2010 American Society for Bone and Mineral Research
Additional Information
How to Cite
Trémollieres, F. A., Pouillès, J.-M., Drewniak, N., Laparra, J., Ribot, C. A. and Dargent-Molina, P. (2010), Fracture risk prediction using BMD and clinical risk factors in early postmenopausal women: Sensitivity of the WHO FRAX tool. J Bone Miner Res, 25: 1002–1009. doi: 10.1002/jbmr.12
- †
Publication History
- Issue published online: 30 APR 2010
- Article first published online: 8 JAN 2010
- Accepted manuscript online: 8 JAN 2010 12:00AM EST
- Manuscript Accepted: 15 DEC 2009
- Manuscript Revised: 20 OCT 2009
- Manuscript Received: 28 JUN 2009
References
- 1, , , , . The diagnosis of osteoporosis. J Bone Miner Res. 2004; 9: 1137–1141.Direct Link:
- 2, , , , . on behalf of the European Foundation for Osteoporosis and Bone Disease. Guidelines for diagnosis and management of osteoporosis. Osteoporos Int. 1997; 7: 390–406.
- 3Food and Drug Administration. Guidelines for Preclinical and Clinical Evaluation of Agents Used in the Prevention and Treatment of Postmenopausal Osteoporosis. Rockville, MD: Division of Metabolism and Endocrine Drug Products; 1994.
- 4. Diagnosis of osteoporosis and assessment of fracture risk. Lancet. 2002; 359: 1929–1936.
- 5, , , et al. The use of clinical risk factors enhances the performances of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int. 2007; 18: 1033–1046.
- 6, , , , . FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int. 2008; 19: 385–397.
- 7, , , , , . Case finding for the management of osteoporosis with FRAX: assessment and intervention thresholds for the UK. Osteoporos Int. 2008; 19: 1395–1408.
- 8, , , . Bone mineral density at menopause does not predict breast cancer incidence. Osteoporos Int. 2008; 19: 1497–1504.
- 9, , , . Assessment of the risk of post-menopausal osteoporosis using clinical factors. Clin Endocrinol (Oxf). 1992; 36: 225–8.Direct Link:
- 10, , , . Influence of early age at menopause on vertebral bone mass. J Bone Miner Res. 1994; 9: 311–5.Direct Link:
- 11, , , et al. Association of cardiovascular risk factors with intima-media thickness of the carotid arteries in early postmenopausal women. Menopause. 2004; 11: 223–30.
- 12, , , et al. Evaluation de la teneur en calcium du régime alimentaire par autoquestionnaire fréquentiel. Rev Rhum. 1991; 58: 99–103.
- 13, , , . Precision and sensitivity of dual-energy X-ray absorptiometry in spinal osteoporosis. J Bone Miner Res. 1991; 6: 997–1001.Direct Link:
- 14, , . Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. Br Med J. 1996; 312: 1254–1259.
- 15, , , , . Risk factors for perimenopausal fractures: a prospective study. Osteoporos Int. 2000; 11: 219–227.
- 16, , , et al. Ten-year absolute risk of osteoporotic fractures according to BMD T score at menopause: the Danish Osteoporosis Prevention Study. J Bone Miner Res. 2006; 21: 796–800.Direct Link:
- 17, , , et al. Predictive value of BMD for hip and other fractures. J Bone Miner Res. 2005; 20: 1185–1194.Direct Link:
- 18, , , . Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res. 2000; 15: 721–739.Direct Link:
- 19, , , et al. A meta-analysis of previous fracture and subsequent fracture risk. Bone. 2004; 35: 375–382.
- 20, , , . 10-year probability of recurrent fracture following wrist and other osteoporotic fractures in a large clinical cohort: an analysis from the Manitoba bone density program. Arch Intern Med. 2008; 168: 2261–2267.
- 21, , , et al. Effects of estrogen plus progestin on the risk of fracture and bone mineral density. The Women's Health Initiative randomized trial. JAMA. 2003; 290: 1729–38.
- 22, , , , , . Reproductive correlates of bone mass in elderly women. J Bone Miner Res. 1993; 8: 901–908.Direct Link:
- 23, , , , , . Effects of estrogen exposure and reproductive factors on bone mineral density and osteoporotic fractures. J Clin Endocrinol Metab. 1995; 80: 2709–2714.
- 24, , , et al. Nulliparity and fracture risk in older women: the Study of Osteoporotic Fracture. J Bone Miner Res. 2003; 18: 893–899.Direct Link:
- 25, , , et al. A family history of fracture and fracture risk: a meta-analysis. Bone. 2004; 35: 1029–1037.
- 26, , , , , . The burden of osteoporotic fractures: A method for setting intervention thresholds. Osteoporos Int. 2001; 12: 417–427.
- 27, , , et al. A simple risk score for the assessment of absolute fracture risk in general practice based on two longitudinal studies. J Bone Miner Res. 2009; 24: 768–774.Direct Link:
- 28, , , et al. An assessment tool for predicting fracture risk in postmenopausal women. Osteoporos Int. 2001; 12: 519–528.
- 29, , , , , . An approach for identifying postmenopausal women age 50–64 years at increased short-term risk for osteoporotic fracture. Osteoporos int. 2007; 18: 1287–1296.
- 30, , , , , . Prognosis of fracture: evaluation of predictive accuracy of the FRAX algorithm and Garvan nomogram. Osteoporos Int. 2009; (in press).
- 31, , . When can a risk factor be used as a worthwhile screening test? BMJ. 1999; 319: 1562–1565.
- 32, , , , . Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker. Am J epidemiol. 2004; 159: 882–890.
- 33. The limitations of risk factors as prognostic tools. N Engl J Med. 2006; 355: 25.

1523-4681/asset/olbannerleft.gif?v=1&s=d7e4c0e37904a489128d3a4e58ba94214db307a9)
1523-4681/asset/olbannerright.gif?v=1&s=854ee0e4d351ead9faaca8bfab3e50b1c7c9d03d)
