Commentary

You have free access to this content

Novel complexities regarding BMPs and fracture healing

  1. Thorsten Schinke,
  2. Michael Amling*

Article first published online: 30 APR 2010

DOI: 10.1002/jbmr.122

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 25, Issue 6, pages 1193–1195, June 2010

Additional Information

How to Cite

Schinke, T. and Amling, M. (2010), Novel complexities regarding BMPs and fracture healing. Journal of Bone and Mineral Research, 25: 1193–1195. doi: 10.1002/jbmr.122

Author Information

  1. Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

*Department of Osteology and Biomechanics, Hamburg University School of Medicine, Martinistrasse 52, Hamburg 20249, Germany.

Publication History

  1. Issue published online: 27 MAY 2010
  2. Article first published online: 30 APR 2010
  3. Accepted manuscript online: 30 APR 2010 12:00AM EST

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (50K)

References

  • 1
    Urist MR. Bone: formation by autoinduction. Science. 1965; 150: 893–899.
  • 2
    Wozney JM, Rosen V, Celeste AJ, et al. Novel regulators of bone formation: molecular clones and activities. Science. 1988; 242: 1528–1534.
  • 3
    Hogan BL. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 1996; 10: 1580–1594.
  • 4
    Chen D, Zhao M, Mundy GR. Bone morphogenetic proteins. Growth Factors. 2004; 22: 233–241.
  • 5
    Wu X, Shi W, Cao X. Multiplicity of BMP signaling in skeletal development. Ann NY Acad Sci. 2007; 1116: 29–49.
    Direct Link:
  • 6
    Gautschi OP, Frey SP, Zellweger R. Bone morphogenetic proteins in clinical applications. Aust NZ J Surg. 2007; 77: 626–631.
    Direct Link:
  • 7
    Chen X, Kidder LS, Lew WD. Osteogenic protein-1-induced bone formation in an infected segmental defect in the rat femur. J Orthop Res. 2002; 20: 142–150.
    Direct Link:
  • 8
    Seeherman H, Li R, Wozney J. A review of preclinical program development for evaluating injectable carriers for osteogenic factors. J Bone Joint Surg Am. 2003; 85: S96–108.
  • 9
    Vögelin E, Jones NF, Huang JI, Brekke JH, Lieberman JR. Healing of a critical-sized defect in the rat femur with use of a vascularized periosteal flap, a biodegradable matrix, and bone morphogenetic protein. J Bone Joint Surg Am. 2005; 87: 1323–1331.
  • 10
    Westerhuis RJ, van Bezooijen RL, Kloen P. Use of bone morphogenetic proteins in traumatology. Injury. 2005; 36: 1405–1412.
  • 11
    Govender S, Csimma C, Genant HK, et al. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am. 2002; 84-A: 2123–2134.
  • 12
    Friedlaender GE, Perry CR, Cole JD, et al. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg Am. 2001; 83: S151–158.
  • 13
    Maniscalco P, Gambera D, Bertone C, Rivera F, Crainz E, Urgelli S. Healing of fresh tibial fractures with OP-1: a preliminary report. Acta Biomed. 2002; 73: 27–33.
  • 14
    Haidar ZS, Hamdy RC, Tabrizian M. Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair: B. Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering. Biotechnol Lett. 2009; 31: 1825–1835.
  • 15
    Minear S, Leucht P, Miller S, Helms JA. rBMP represses Wnt signalling and influences skeletal progenitor cell fate specification during bone repair. J Bone Miner Res. 2010; 25: 1196–1207.
  • 16
    Diefenderfer DL, Osyczka AM, Garino JP, Leboy PS. Regulation of BMP-induced transcription in cultured human bone marrow stromal cells. J Bone Joint Surg Am. 2003; 85: S19–28.
  • 17
    Diefenderfer DL, Osyczka AM, Reilly GC, Leboy PS. BMP responsiveness in human mesenchymal stem cells. Connect Tissue Res. 2003; 44: S305–311.
  • 18
    Lustig B, Jerchow B, Sachs M, et al. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol. 2002; 22: 1184–1193.
  • 19
    ten Berge D, Brugmann SA, Helms JA, Nusse R. Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development. Development. 2008; 135: 3247–3257.
  • 20
    Haynesworth SE, Goshima J, Goldberg VM, Caplan AI. Characterization of cells with osteogenic potential from human marrow. Bone. 1992; 13: 81–88.
  • 21
    Sen MK, Miclau T. Autologous iliac crest bone graft: should it still be the gold standard for treating nonunions? Injury. 2007; 38: S75–80.
  • 22
    Claes L, Veeser A, Göckelmann M, Simon U, Ignatius A. A novel model to study metaphyseal bone healing under defined biomechanical conditions. Arch Orthop Trauma Surg. 2009; 129: 923–928.
View Full Article (HTML) Get PDF (50K)