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Guidelines for assessment of bone microstructure in rodents using micro–computed tomography
Article first published online: 7 JUN 2010
DOI: 10.1002/jbmr.141
Copyright © 2010 American Society for Bone and Mineral Research
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Bouxsein, M. L., Boyd, S. K., Christiansen, B. A., Guldberg, R. E., Jepsen, K. J. and Müller, R. (2010), Guidelines for assessment of bone microstructure in rodents using micro–computed tomography. J Bone Miner Res, 25: 1468–1486. doi: 10.1002/jbmr.141
Publication History
- Issue published online: 30 JUN 2010
- Article first published online: 7 JUN 2010
- Manuscript Accepted: 21 MAY 2010
- Manuscript Revised: 11 MAY 2010
- Manuscript Received: 17 MAR 2010
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- 1, , , , , , Adult Stem Cell Mobilization Enhances Intramembranous Bone Regeneration: A Pilot Study, Clinical Orthopaedics and Related Research®, 2012,
- 2, , , , , , , Anatomical distribution of the degree of mineralization of bone tissue in human femoral neck: Impact on biomechanical properties, Bone, 2012, 50, 4, 876
- 3, , , , , , , , , , , , Anti IL-17A therapy inhibits bone loss in TNF-α-mediated murine arthritis by modulation of the T-cell balance, European Journal of Immunology, 2012, 42, 2Direct Link:
- 4, , , , , Bone turnover markers correlate with implant fixation in a rat model using LPS-doped particles to induced implant loosening, Journal of Biomedical Materials Research Part A, 2012, 100A, 4Direct Link:
- 5, , , , , , Effects of Different Therapeutic Ultrasound Intensities on Fracture Healing in Rats, Ultrasound in Medicine & Biology, 2012, 38, 5, 745
- 6, , , , , , , , Fracture healing in protease-activated receptor-2 deficient mice, Journal of Orthopaedic Research, 2012, 30, 7Direct Link:
- 7, , , Gremlin1 is required for skeletal development and postnatal skeletal homeostasis, Journal of Cellular Physiology, 2012, 227, 1Direct Link:
- 8, , , , , Imaging of Cellular Spread on a Three-Dimensional Scaffold by Means of a Novel Cell-Labeling Technique for High-Resolution Computed Tomography, Tissue Engineering Part C: Methods, 2012, 18, 3, 167
- 9
- 10, , , , , , , , , , , , , , , , , , , Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin, Journal of Clinical Investigation, 2012, 122, 5, 1791
- 11, , , Influence of Mineralization and Microporosity on Tissue Elasticity: Experimental and Numerical Investigation on Mineralized Turkey Leg Tendons, Calcified Tissue International, 2012, 90, 4, 319
- 12, , Is micro-computed tomography reliable to determine the microstructure of the maxillary alveolar bone?, Clinical Oral Implants Research, 2012, 23, 6Direct Link:
- 13, , , , Low intensity pulsed ultrasound enhances fracture healing in both ovariectomy-induced osteoporotic and age-matched normal bones, Journal of Orthopaedic Research, 2012, 30, 1Direct Link:
- 14, , , , , , Low-Dose, Ionizing Radiation and Age-Related Changes in Skeletal Microarchitecture, Journal of Aging Research, 2012, 2012, 1
- 15, , , , , , , Low-dose rhBMP2/7 heterodimer to reconstruct peri-implant bone defects: a micro-CT evaluation, Journal of Clinical Periodontology, 2012, 39, 1Direct Link:
- 16, , , , , Micro and macroarchitectural changes at the tibia after botulinum toxin injection in the growing rat, Bone, 2012, 50, 4, 858
- 17, , , , , , Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis, Osteoarthritis and Cartilage, 2012,
- 18, , , , , , , , Overexpression of DMP1 accelerates mineralization and alters cortical bone biomechanical properties in vivo, Journal of the Mechanical Behavior of Biomedical Materials, 2012, 5, 1, 1
- 19, , , , , , , , , , Phospholipase Cγ2 is required for basal but not oestrogen deficiency–induced bone resorption, European Journal of Clinical Investigation, 2012, 42, 1Direct Link:
- 20, , , , , , , Proteinase-activated receptor-2 is required for normal osteoblast and osteoclast differentiation during skeletal growth and repair, Bone, 2012, 50, 3, 704
- 21, , , , , , , , , , , Proteoglycan 4: A dynamic regulator of skeletogenesis and parathyroid hormone skeletal anabolism, Journal of Bone and Mineral Research, 2012, 27, 1Direct Link:
- 22, , , , , , , , Repair of rabbit ulna segmental bone defect using freshly isolated adipose-derived stromal vascular fraction, Cytotherapy, 2012, 14, 3, 296
- 23, , , , , Site-specific changes in bone microarchitecture, mineralization, and stiffness during lactation and after weaning in mice, Journal of Bone and Mineral Research, 2012, 27, 4Direct Link:
- 24
- 25, , , , , , , , , , , , Spine degeneration in a murine model of chronic human tobacco smokers, Osteoarthritis and Cartilage, 2012,
- 26, , , , , The Effect of Level and Downhill Running on Cortical and Trabecular Bone in Growing Rats, Calcified Tissue International, 2012, 90, 5, 429
- 27, , , , , , , , , , , , , , , The transient receptor potential channel TRPV6 is dynamically expressed in bone cells but is not crucial for bone mineralization in mice, Journal of Cellular Physiology, 2012, 227, 5Direct Link:
- 28, , , , , , , , , Three-dimensional structure of the shell plate assembly of the chiton Tonicella marmorea and its biomechanical consequences, Journal of Structural Biology, 2012, 177, 2, 314
- 29, , , , Three-dimensional dynamic bone histomorphometry, Journal of Bone and Mineral Research, 2012, 27, 2Direct Link:
- 30, , , , 3D characterization of bone strains in the rat tibia loading model, Biomechanics and Modeling in Mechanobiology, 2011, 11, 3-4, 403
- 31, , , , , , Application of in vivo micro-computed tomography in the temporal characterisation of subchondral bone architecture in a rat model of low-dose monosodium iodoacetate-induced osteoarthritis, Arthritis Research & Therapy, 2011, 13, 6, R210
- 32, , , , Assessment of Trabecular Bone Architecture and Intrinsic Properties of Cortical bone Tissue in a Mouse Model of Chronic Kidney Disease, Journal of Hard Tissue Biology, 2011, 20, 2, 79
- 33, , , , , Attenuated anabolic response to exercise in lamin A/C haploinsufficient mice, Bone, 2011, 49, 3, 412
- 34, , Automated quantitative microstructural analysis of metastatically involved vertebrae: Effects of stereologic model and spatial resolution, Medical Engineering & Physics, 2011, 33, 2, 188
- 35, , , , , Cell line IDG-SW3 replicates osteoblast-to-late-osteocyte differentiation in vitro and accelerates bone formation in vivo, Journal of Bone and Mineral Research, 2011, 26, 11Direct Link:
- 36, , , , , , Chlorthalidone improves vertebral bone quality in genetic hypercalciuric stone-forming rats, Journal of Bone and Mineral Research, 2011, 26, 8Direct Link:
- 37, , , , , , , Comparison of 2D and 3D bone microarchitecture evaluation at the femoral neck, among postmenopausal women with hip fracture or hip osteoarthritis, Bone, 2011, 49, 5, 1055
- 38, , , , , , Connexin43 deficiency reduces the sensitivity of cortical bone to the effects of muscle paralysis, Journal of Bone and Mineral Research, 2011, 26, 9Direct Link:
- 39, , , Deriving tissue density and elastic modulus from microCT bone scans, Bone, 2011, 49, 5, 931
- 40, , , , , , , , Development of micro-CT protocols for in vivo follow-up of mouse bone architecture without major radiation side effects, Bone, 2011, 49, 4, 613
- 41, , , , , , Different effects on bone strength and cell differentiation in pre pubertal caloric restriction versus hypothalamic suppression, Bone, 2011, 49, 4, 810
- 42, , , Direct visualization and quantification of bone growth into porous titanium implants using micro computed tomography, Journal of Materials Science: Materials in Medicine, 2011, 22, 5, 1321
- 43, , , , , , , , , , , Dose response of bone-targeted enzyme replacement for murine hypophosphatasia, Bone, 2011, 49, 2, 250
- 44, , , , , , , , , , , Erythropoietin stimulates bone formation, cell proliferation, and angiogenesis in a femoral segmental defect model in mice, Bone, 2011, 49, 5, 1037
- 45, , , , Experimental and finite element analysis of the mouse caudal vertebrae loading model: prediction of cortical and trabecular bone adaptation, Biomechanics and Modeling in Mechanobiology, 2011, 11, 1-2, 221
- 46, , , , , , , FGF-23/Klotho signaling is not essential for the phosphaturic and anabolic functions of PTH, Journal of Bone and Mineral Research, 2011, 26, 9Direct Link:
- 47, , , , , , , , , , , , Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice, Journal of Clinical Investigation, 2011, 121, 9, 3492
- 48, , , , , , Imaging technologies for preclinical models of bone and joint disorders, EJNMMI Research, 2011, 1, 1, 11
- 49, , , , , , , , In vivo bone regeneration with injectable chitosan/hydroxyapatite/collagen composites and mesenchymal stem cells, Frontiers of Materials Science, 2011, 5, 3, 301
- 50, , , , , In vivo loading increases mechanical properties of scaffold by affecting bone formation and bone resorption rates, Bone, 2011, 49, 6, 1357
- 51, , , , , In vivo validation of a computational bone adaptation model using open-loop control and time-lapsed micro-computed tomography, Bone, 2011, 49, 6, 1166
- 52, , , , , , , , , , , Increasing duration of type 1 diabetes perturbs the strengthâstructure relationship and increases brittleness of bone, Bone, 2011, 48, 4, 733
- 53, , , , , , Indentation experiments and simulation of ovine bone using a viscoelastic-plastic damage model, Journal of Materials Research, 2011, 27, 01, 368
- 54, , , , , , , , , , , , , , , Interferon-γ plays a role in bone formation in vivo and rescues osteoporosis in ovariectomized mice, Journal of Bone and Mineral Research, 2011, 26, 7Direct Link:
- 55, , , , , , Lamin A/C deficiency is associated with fat infiltration of muscle and bone, Mechanisms of Ageing and Development, 2011, 132, 11-12, 552
- 56, , , , , , , , Local delivery of FTY720 accelerates cranial allograft incorporation and bone formation, Cell and Tissue Research, 2011, 347, 3, 553
- 57, , , , , Longitudinal Assessment of In Vivo Bone Dynamics in a Mouse Tail Model of Postmenopausal Osteoporosis, Calcified Tissue International, 2011, 90, 2, 108
- 58, , , , , , , , , , , Low bone accrual is associated with osteocyte apoptosis in alcohol-induced osteopenia, Bone, 2011, 49, 3, 543
- 59, , , , , , Microcomputed tomographyâbased structural analysis of various bone tissue regeneration models, Nature Protocols, 2011, 6, 1, 105
- 60, , , , , , , , MicroCT morphometry analysis of mouse cancellous bone: Intra- and inter-system reproducibility, Bone, 2011, 49, 3, 580
- 61, , , , , Mouse tail vertebrae adapt to cyclic mechanical loading by increasing bone formation rate and decreasing bone resorption rate as shown by time-lapsed in vivo imaging of dynamic bone morphometry, Bone, 2011, 49, 6, 1340
- 62, , , , , , , , , , , Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model, Journal of Bone and Mineral Research, 2011, 26, 7Direct Link:
- 63, , , , , , , Physiological function of the angiotensin AT1a receptor in bone remodeling, Journal of Bone and Mineral Research, 2011, 26, 12Direct Link:
- 64, , , , , , , , , , Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development, Blood, 2011, 119, 3, 736
- 65, , , , , , , , , , , Regulation of postnatal trabecular bone formation by the osteoblast endothelin A receptor, Journal of Bone and Mineral Research, 2011, 26, 10Direct Link:
- 66, , , , Serial FIB/SEM imaging for quantitative 3D assessment of the osteocyte lacuno-canalicular network, Bone, 2011, 49, 2, 304
- 67, , , , , , , , Skeletal Remodeling Following Clinically Relevant Radiation-Induced Bone Damage Treated with Zoledronic Acid, Calcified Tissue International, 2011, 90, 1, 40
- 68, , , , Standardized Three-Dimensional Volumes of Interest with Adapted Surfaces for More Precise Subchondral Bone Analyses by Micro-Computed Tomography, Tissue Engineering Part C: Methods, 2011, 17, 4, 475
- 69, , , , , , Subchondral trabecular structural changes in the proximal tibia in an ovine model of increased bone turnover, Journal of Anatomy, 2011, 218, 6Direct Link:
- 70, , , , , , , , , , Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts, Bone, 2011, 48, 5, 1117
- 71, , , , The bone architecture is enhanced with combined PTH and alendronate treatment compared to monotherapy while maintaining the state of surface mineralization in the OVX rat, Bone, 2011, 49, 2, 225
- 72, , , , , , The importance of murine cortical bone microstructure for microcrack initiation and propagation, Bone, 2011, 49, 6, 1186
- 73, , , , , , , , , Thyroid hormone receptor β mediates thyroid hormone effects on bone remodeling and bone mass, Journal of Bone and Mineral Research, 2011, 26, 9Direct Link:
- 74, , , Vertical ground reaction forces diminish in mice after botulinum toxin injection, Journal of Biomechanics, 2011, 44, 4, 637
- 75
- 76, , , Muscle Changes Can Account for Bone Loss After Botulinum Toxin Injection, Calcified Tissue International, 2010, 87, 6, 541

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