The December 2010 issue of Journal of Bone and Mineral Research was published online on 23 Nov 2010. A pagination error was subsequently identified. This notice is included to indicate that the pagination is now correct and authoritative [20 January 2011].
Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures†
Article first published online: 18 JUN 2010
Copyright © 2010 American Society for Bone and Mineral Research
Journal of Bone and Mineral Research
Volume 25, Issue 12, pages 2572–2581, December 2010
How to Cite
Stein, E. M., Liu, X. S., Nickolas, T. L., Cohen, A., Thomas, V., McMahon, D. J., Zhang, C., Yin, P. T., Cosman, F., Nieves, J., Guo, X. E. and Shane, E. (2010), Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures. J Bone Miner Res, 25: 2572–2581. doi: 10.1002/jbmr.152
- Issue published online: 23 NOV 2010
- Article first published online: 18 JUN 2010
- Accepted manuscript online: 18 JUN 2010 12:00AM EST
- Manuscript Accepted: 4 JUN 2010
- Manuscript Revised: 12 MAY 2010
- Manuscript Received: 1 MAR 2010
Measurement of areal bone mineral density (aBMD) by dual-energy x-ray absorptiometry (DXA) has been shown to predict fracture risk. High-resolution peripheral quantitative computed tomography (HR-pQCT) yields additional information about volumetric BMD (vBMD), microarchitecture, and strength that may increase understanding of fracture susceptibility. Women with (n = 68) and without (n = 101) a history of postmenopausal fragility fracture had aBMD measured by DXA and trabecular and cortical vBMD and trabecular microarchitecture of the radius and tibia measured by HR-pQCT. Finite-element analysis (FEA) of HR-pQCT scans was performed to estimate bone stiffness. DXA T-scores were similar in women with and without fracture at the spine, hip, and one-third radius but lower in patients with fracture at the ultradistal radius (p < .01). At the radius fracture, patients had lower total density, cortical thickness, trabecular density, number, thickness, higher trabecular separation and network heterogeneity (p < .0001 to .04). At the tibia, total, cortical, and trabecular density and cortical and trabecular thickness were lower in fracture patients (p < .0001 to .03). The differences between groups were greater at the radius than at the tibia for inner trabecular density, number, trabecular separation, and network heterogeneity (p < .01 to .05). Stiffness was reduced in fracture patients, more markedly at the radius (41% to 44%) than at the tibia (15% to 20%). Women with fractures had reduced vBMD, microarchitectural deterioration, and decreased strength. These differences were more prominent at the radius than at the tibia. HR-pQCT and FEA measurements of peripheral sites are associated with fracture prevalence and may increase understanding of the role of microarchitectural deterioration in fracture susceptibility. © 2010 American Society for Bone and Mineral Research.