Original Article
You have full text access to this OnlineOpen article
Fracture risk in women with breast cancer: A population-based study
Article first published online: 18 APR 2012
DOI: 10.1002/jbmr.1556
Copyright © 2012 American Society for Bone and Mineral Research
Additional Information
How to Cite
Melton, L. J., Hartmann, L. C., Achenbach, S. J., Atkinson, E. J., Therneau, T. M. and Khosla, S. (2012), Fracture risk in women with breast cancer: A population-based study. J Bone Miner Res, 27: 1196–1205. doi: 10.1002/jbmr.1556
Publication History
- Issue published online: 18 APR 2012
- Article first published online: 18 APR 2012
- Accepted manuscript online: 18 JAN 2012 12:20PM EST
- Manuscript Accepted: 12 JAN 2012
- Manuscript Revised: 3 JAN 2012
- Manuscript Received: 21 SEP 2011
References
- 1, , , Risk of osteoporotic fractures in women with breast cancer: a population-based cohort study. J Chronic Dis. 1987; 40: 105–13.
- 2, Low risk of hip fracture among elderly breast cancer survivors. Ann Epidemiol. 2003; 13: 698–703.
- 3, , , , , , Hip fractures in women with breast cancer. Am J Epidemiol. 1990; 132: 877–83.
- 4, Estrogen carcinogenesis in breast cancer. N Engl J Med. 2006; 354: 270–82.
- 5, , Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev. 2002; 23: 279–302.
- 6, , , , , , , , , , , , , , , , Predictive value of BMD for hip and other fractures. J Bone Miner Res. 2005; 20: 1185–94.
- 7, Bone mineral density and prediction of non-osteoporotic disease. Maturitas. 2010; 65: 348–51.
- 8, Reduced cancer morbidity and mortality in a prospective cohort of women with distal forearm fractures. Am J Epidemiol. 1992; 136: 422–7.
- 9, , , , Reduced risk of breast and endometrial cancer among women with hip fractures (Sweden). Cancer Causes Control. 1994; 5: 523–8.
- 10, , , , , , , Fracture history and risk of breast and endometrial cancer. Am J Epidemiol. 2001; 153: 1071–8.
- 11, , Is there a reduced risk of breast cancer among women with hip fractures?. Eur J Epidemiol. 1999; 15: 313–5.
- 12, Epidemiology and outcomes of osteoporotic fractures. Lancet. 2002; 359: 1761–7.
- 13, , , , , A high incidence of vertebral fracture in women with breast cancer. Br J Cancer. 1999; 79: 1179–81.
- 14, Osteoporosis due to cancer treatment: pathogenesis and management. J Clin Oncol. 2000; 18: 1570–93.
- 15, , , , , , , , , , NCCN Task Force Report: bone health in cancer care. J Natl Compr Canc Netw. 2009; 7( Suppl 3): S1–32.
- 16, , , , , , , , Adjuvant treatment and onset of menopause predict weight gain after breast cancer diagnosis. J Clin Oncol. 1999; 17: 120–9.
- 17, , , , , Fracture risk after bilateral oophorectomy in elderly women. J Bone Miner Res. 2003; 18: 900–5.
- 18, , , , , , , Relationship of volumetric bone density and structural parameters at different skeletal sites to sex steroid levels in women. J Clin Endocrinol Metab. 2005; 90: 5096–103.
- 19, Aging and osteoporosis in breast and prostate cancer. CA Cancer J Clin. 2011; 61: 139–56.
- 20, , , , , , , Risk of cancer treatment-associated bone loss and fractures among women with breast cancer receiving aromatase inhibitors. Clin Breast Cancer. 2006; 7: 127–32.
- 21, , Effect of tamoxifen and aromatase inhibitors on the risk of fractures in women with breast cancer. Calcif Tissue Int. 2008; 82: 334–40.
- 22, , , , Fracture risk and adjuvant hormonal therapy among a population-based cohort of older female breast cancer patients. Osteoporos Int. 2011; 22: 2847–55.
- 23, , , , Lack of evidence for fracture prevention in early breast cancer bisphosphonate trials: a meta-analysis. Gynecol Oncol. 2010; 117: 139–45.
- 24, , Screening for second cancers and osteoporosis in long-term survivors. Cancer Pract. 2000; 8: 282–90.
- 25, Bone health in postmenopausal women with early breast cancer: how protective is tamoxifen?. Cancer Treat Rev. 2007; 33: 506–13.
- 26, , , , Femoral fractures in postmenopausal breast cancer patients treated with adjuvant tamoxifen. Breast Cancer Res Treat. 1996; 39: 321–6.
- 27, , , , Tamoxifen use and osteoporotic fracture risk: a population-based analysis. J Clin Oncol. 2008; 26: 5227–32.
- 28, , , , , Adjuvant therapy for breast cancer: practice patterns of community physicians. J Clin Oncol. 2002; 20: 1809–17.
- 29, , , , , Evaluation of trends in the cost of initial cancer treatment. J Natl Cancer Inst. 2008; 100: 888–97.
- 30, , , Cancer statistics, 2010. CA Cancer J Clin. 2010; 60: 277–300.
- 31History of the Rochester Epidemiology Project. Mayo Clin Proc. 1996; 71: 266–74.
- 32The threat to medical-records research. N Engl J Med. 1997; 337: 1466–70.
- 33USDHHS. Bone Health and Osteoporosis: A Report of the Surgeon General. Rockville, MD: US Department of Health and Human Services; 2004.
- 34, , Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992; 45: 613–9.
- 35, , , Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985–1989. J Bone Miner Res. 1992; 7: 221–7.
- 36, , Fracture incidence in Olmsted County, Minnesota: comparison of urban with rural rates and changes in urban rates over time. Osteoporos Int. 1999; 9: 29–37.
- 37, , , , , Fracture risk following bilateral orchiectomy. J Urol. 2003; 169: 1747–50.
- 38Some simple approximate tests for Poisson variates. Biometrika. 1953; 40: 354–60.
- 39, Non-parametric estimation from incomplete observations. J Am Stat Assoc. 1958; 53: 457–81.
- 40, , , Estimation of failure probabilities in the presence of competing risks: new representations of old estimators. Stat Med. 1999; 18: 695–706.
- 41, The Statistical Analysis of Failure Time Data. New York: John Wiley and Sons; 1980.
- 42, Modeling Survival Data: Extending the Cox Model. New York: Springer-Verlag; 2000.
- 43Bias reduction of maximum likelihood estimates. Biometrika. 1993; 80: 27–38.
- 44, , , , , Asymptomatic vertebral deformity as a major risk factor for subsequent fractures and mortality: a long-term prospective study. J Bone Miner Res. 2005; 20: 1349–55.
- 45, , , , , , , , , , Relation of vertebral fractures to bone density, structure and strength. J Bone Miner Res. 2010; 25: 1922–30.
- 46, , , , Updated fracture incidence rates for the US version of FRAX. Osteoporos Int. 2010; 21: 25–33.
- 47, , Fracture risk in patients with different types of cancer. Acta Oncol. 2009; 48: 105–15.
- 48, , , , , , , , Fracture risk among breast cancer survivors: results from the Women's Health Initiative Observational Study. Arch Intern Med. 2005; 165: 552–8.
- 49, , , , , , , Fracture risk increases after diagnosis of breast or other cancers in postmenopausal women: results from the Women's Health Initiative. Osteoporos Int. 2009; 20: 527–36.
- 50, Minimizing bias due to confounding by indication in comparative effectiveness research: the importance of restriction. JAMA. 2010; 304: 897–8.
- 51, , , , , , , , , , , , , , , , , Systematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis. Ann Intern Med. 2008; 148: 197–213.
- 52, , , , , Limits of observational data in determining outcomes from cancer therapy. Cancer. 2008; 112: 2456–66.
- 53, , , , , , , , , , , , A meta-analysis of prior corticosteroid use and fracture risk. J Bone Miner Res. 2004; 19: 893–9.
- 54, , Methotrexate, azathioprine, cyclosporine, and risk of fracture. Calcif Tissue Int. 2006; 79: 69–75.
- 55, , , , , , , , , , “ Pathologic” fractures: should these be included in epidemiologic studies of osteoporotic fractures? Osteoporos Int. 2009; 20: 1969–72.
- 56, , , , , , , Secular trends in hip fracture incidence and recurrence. Osteoporos Int. 2009; 20: 687–94.
- 57, , , , , , , The decrease in breast-cancer incidence in 2003 in the United States. N Engl J Med. 2007; 356: 1670–4.

1523-4681/asset/olbannerleft.gif?v=1&s=d7e4c0e37904a489128d3a4e58ba94214db307a9)
1523-4681/asset/olbannerright.gif?v=1&s=854ee0e4d351ead9faaca8bfab3e50b1c7c9d03d)
