• 1
    Watts NB, Ettinger B, LeBoff MS. Perspective: FRAX facts. J Bone Miner Res. 2009; 24(6): 9759.
  • 2
    Kanis JA, Borgstrom F, De Laet C, Johansson H, Johnell O, Jonsson B, Oden A, Zethraeus N, Pfleger B, Khaltaev N. Assessment of fracture risk. Osteoporos Int. 2005; 16(6): 5819.
  • 3
    Setty N, Leboff MS, Thornhill TS, Rinaldi G, Glowacki J. Underestimated fracture probability in patients with unilateral hip osteoarthritis as calculated by FRAX. J Clin Densitom. 2011; 14(4): 44752.
  • 4
    LeBoff MS, Kohlmeier L, Hurwitz S, Franklin J, Wright J, Glowacki J. Occult vitamin D deficiency in postmenopausal US women with acute hip fracture. JAMA. 1999; 281(16): 150511.
  • 5
    Clarke BL, Khosla S. Physiology of bone loss. Radiol Clin North Am. 2010; 48(3): 48395.
  • 6
    Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science. 1997; 276(5309): 714.
  • 7
    Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. Multilineage potential of adult human mesenchymal stem cells. Science. 1999; 284(5411): 1437.
  • 8
    Zhou S. From bone to brain: human skeletal stem cell therapy for stroke. central nervous system agents in medicinal chemistry. 2011; 11(2): 15763.
  • 9
    Mueller SM, Glowacki J. Age-related decline in the osteogenic potential of human bone marrow cells cultured in three-dimensional collagen sponges. J Cell Biochem. 2001; 82(4): 58390.
  • 10
    Zhou S, Greenberger JS, Epperly MW, Goff JP, Adler C, Leboff MS, Glowacki J. Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts. Aging Cell. 2008; 7(3): 33543.
  • 11
    Zhou S, Bueno EM, Kim SW, Amato I, Shen L, Hahne J, Bleiberg I, Morley P, Glowacki J. Effects of age on parathyroid hormone signaling in human marrow stromal cells. Aging Cell. 2011; 10(5): 7808.
  • 12
    Geng S, Zhou S, Glowacki J. Age-related decline in osteoblastogenesis and 1α-hydroxylase/CYP27B1 in human mesenchymal stem cells: stimulation by parathyroid hormone. Aging Cell. 2011; 10(6): 96271.
  • 13
    Nishida S, Endo N, Yamagiwa H, Tanizawa T, Takahashi HE. Number of osteoprogenitor cells in human bone marrow markedly decreases after skeletal maturation. J Bone Miner Metab. 1999; 17(3): 1717.
  • 14
    D'Ippolito G, Diabira S, Howard GA, Roos BA, Schiller PC. Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells. Bone. 2006; 39(3): 51322.
  • 15
    Cheleuitte D, Mizuno S, Glowacki J. In vitro secretion of cytokines by human bone marrow: effects of age and estrogen status. J Clin Endocrinol Metab. 1998; 83(6): 204351.
  • 16
    Makhluf HA, Mueller SM, Mizuno S, Glowacki J. Age-related decline in osteoprotegerin expression by human bone marrow cells cultured in three-dimensional collagen sponges. Biochem Biophys Res Comm. 2000; 268(3): 66972.
  • 17
    Shen L, Zhou S, Glowacki J. Effects of age and gender on Wnt gene expression in human bone marrow stromal cells. J Cell Biochem. 2009; 106(2): 33743.
  • 18
    Liu P, Oyajobi BO, Russell RG, Scutt A. Regulation of osteogenic differentiation of human bone marrow stromal cells: interaction between transforming growth factor-β and 1,25(OH)2vitamin D3 In vitro. Calcif Tissue Int. 1999; 65(2): 17380.
  • 19
    Zhou S, LeBoff MS, Glowacki J. Vitamin D metabolism and action in human bone marrow stromal cells. Endocrinology. 2010; 151(1): 1422.
  • 20
    Geng S, Zhou S, Glowacki J. Effects of 25-hydroxyvitamin D3 on proliferation and osteoblast differentiation of human marrow stromal cells require CYP27B1/1α-hydroxylase. J Bone Miner Res. 2011; 26(5): 114553.
  • 21
    Gordon AM, Hurwitz S, Shapiro CL, Leboff MS. Premature ovarian failure and body composition changes with adjuvant chemotherapy for breast cancer. Menopause. 2011; 18(11): 12448.
  • 22
    Kelly TL, Wilson KE, Heymsfield SB. Dual energy X-ray absorptiometry body composition reference values from NHANES. PLoS One. 2009; 4(9): e7038.
  • 23
    Byrne TA, Morrissey TB, Gatzen C, Benfell K, Nattakom TV, Scheltinga MR, LeBoff MS, Ziegler TR, Wilmore DW. Anabolic therapy with growth hormone accelerates protein gain in surgical patients requiring nutritional rehabilitation. Ann Surg. 1993; 218(4): 40016 discussion 416-8.
  • 24
    Zhou S, Lechpammer S, Greenberger JS, Glowacki . Hypoxia inhibition of adipocytogenesis in human bone marrow stromal cells requires transforming growth factor-β/Smad3 signaling. J Biol Chem. 2005; 280(24): 2268896.
  • 25
    Zhou S, Zilberman Y, Wassermann K, Bain SD, Sadovsky Y, Gazit D. Estrogen modulates estrogen receptor alpha and beta expression, osteogenic activity, and apoptosis in mesenchymal stem cells (MSCs) of osteoporotic mice. J Cell Biochem Suppl. 2001; Suppl 36: 14455.
  • 26
    Lomri A, Fromigue O, Hott M, Marie PJ. Genomic insertion of the SV-40 large T oncogene in normal adult human trabecular osteoblastic cells induces cell growth without loss of the differentiated phenotype. Calcif Tissue Int. 1999; 64(5): 394401.
  • 27
    Gordeladze JO, Drevon CA, Syversen U, Reseland JE. Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization: impact on differentiation markers, apoptosis, and osteoclastic signaling. J Cell Biochem. 2002; 85(4): 82536.
  • 28
    Zhou S, Glowacki J, Yates KE. Comparison of TGF-β/BMP pathways signaled by demineralized bone powder and BMP-2 in human dermal fibroblasts. J Bone Miner Res. 2004; 19(10): 173241.
  • 29
    Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011; 96(7): 191130.
  • 30
    Rosen CJ, Glowacki J, Craig W. Sex steroids, the insulin-like growth factor regulatory system, and aging: implications for the management of older postmenopausal women. J Nutr Health Aging. 1998; 2(1): 3944.
  • 31
    Gordon CM, LeBoff MS, Glowacki J. Adrenal and gonadal steroids inhibit IL-6 secretion by human marrow cells. Cytokine. 2001; 16(5): 17886.
  • 32
    Looker AC, Dawson-Hughes B, Calvo MS, Gunter EW, Sahyoun NR. Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone. 2002; 30(5): 7717.
  • 33
    Ferrari P, Xiao J, Ukich A, Irish A. Estimation of glomerular filtration rate: does haemoglobin discriminate between ageing and true CKD?. Nephrol Dial Transplant. 2009; 24(6): 182833.
  • 34
    Choudhury D, Levi M. Kidney aging-inevitable or preventable?. Nat Rev Nephrol. 2011; 7(12): 70617.
  • 35
    Glassock RJ, Winearls C. Ageing and the glomerular filtration rate: truths and consequences. Trans Am Clin Climatol Assoc. 2009; 120: 41928.
  • 36
    Rejnmark L, Vestergaard P, Heickendorff L, Mosekilde L. Determinants of plasma PTH and their implication for defining a reference interval. Clin Endocrinol. 2011; 74(1): 3743.
  • 37
    Carnevale V, Nieddu L, Romagnoli E, Battista C, Mascia ML, Chiodini I, Eller-Vainicher C, Frusciante V, Santini SA, La Porta M, Minisola S, Scillitani A. Regulation of PTH secretion by 25-hydroxyvitamin D and ionized calcium depends on vitamin D status: a study in a large cohort of healthy subjects. Bone. 2010; 47(3): 62630.
  • 38
    Holick MF. Vitamin D deficiency. N Engl J Med. 2007; 357(3): 26681.
  • 39
    Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006; 84(1): 1828.
  • 40
    Holick MF, Siris ES, Binkley N, Beard MK, Khan A, Katzer JT, Petruschke RA, Chen E, de Papp AE. Prevalence of vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy. J Clin Endocrinol Metab. 2005; 90(6): 321524.
  • 41
    Institute of Medicine. 2011 Dietary reference intakes for calcium and vitamin D. Washington, DC: The National Academies Press; 2011.
  • 42
    Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011; 96(1): 538.
  • 43
    Dawson-Hughes B, Mithal A, Bonjour JP, Boonen S, Burckhardt P, Fuleihan GE, Josse RG, Lips P, Morales-Torres J, Yoshimura N. IOF position statement: vitamin D recommendations for older adults. Osteoporos Int. 2010; 21(7): 11514.
  • 44
    Glowacki J, Hurwitz S, Thornhill TS, Kelly M, LeBoff ML. Osteoporosis and vitamin D deficiency among postmenopausal osteoarthritic women undergoing total hip arthroplasty. J Bone Joint Surg. 2003; 85A(12): 23717.
  • 45
    Glowacki J. Osteoarthritis and osteoporosis: coexistence of osteoporosis in patients with osteoarthritis. Minerva Ortop Traumatol. 2010 April; 61(2): 11522.
  • 46
    Reid IR. Relationships between fat and bone. Osteoporos Int. 2008; 19(5): 595606.
  • 47
    Noh H, Yu MR, Kim HJ, Jeon JS, Kwon SH, Jin SY, Lee J, Jang J, Park JO, Ziyadeh F, Han DC, Lee HB. Uremia induces functional incompetence of bone marrow-derived stromal cells. Nephrol Dial Transplant. 2012 Jan; 27(1): 21825.
  • 48
    Huff NK, Spencer ND, Gimble JM, Bagby GJ, Nelson S, Lopez MJ. Impaired expansion and multipotentiality of adult stromal cells in a rat chronic alcohol abuse model. Alcohol. 2011; 45(4): 393402.
  • 49
    von Hurst PR, Stonehouse W, Kruger MC, Coad J. Vitamin D supplementation suppresses age-induced bone turnover in older women who are vitamin D deficient. J Steroid Biochem Mol Biol. 2010; 121(1–2): 2936.