• 1
    Premaor MO, Pilbrow L, Tonkin C, Parker RA, Compston J. Obesity and fractures in postmenopausal women. J Bone Miner Res. 2010; 25: 2927.
  • 2
    Compston JE, Watts NB, Chapurlat R, Cooper C, Boonen S, Greenspan S, Pfeilschifter J, Silverman S, Díez-Pérez A, Lindsay R, Saag KG, Netelenbos JC, Gehlbach S, Hooven FH, Flahive J, Adachi JD, Rossini M, Lacroix AZ, Roux C, Sambrook PN, Siris ES, Glow Investigators. Obesity is not protective against fracture in postmenopausal women: GLOW. Am J Med. 2011; 124: 104350.
  • 3
    Gnudi S, Sitta E, Lisi L. Relationship of body mass index with main limb fragility fractures in postmenopausal women. J Bone Miner Metab. 2009; 27: 47984.
  • 4
    Bergkvist D, Hekmat K, Svensson T, Dahlberg L. Obesity in orthopedic patients. Surg Obes Relat Dis. 2009; 5: 6702.
  • 5
    Pirro M, Fabbriciani G, Leli C, Callarelli L, Manfredelli MR, Fioroni C, Mannarino MR, Scarponi AM, Mannarino E. High weight or body mass index increase the risk of vertebral fractures in postmenopausal osteoporotic women. J Bone Miner Metab. 2010; 228: 8893.
  • 6
    Prieto-Alhambra D, Premaor MO, Fina Avilés F, Hermosilla E, Martinez-Laguna D, Carbonell-Abella C, Nogués X, Compston JE, Díez-Pérez A. The association between fracture and obesity is site-dependent: a population-based study in postmenopausal women. J Bone Miner Res. 2012; 27: 294300.
  • 7
    Kanis JA, on behalf of the World Health Organization Scientific Group. Assessment of osteoporosis at the primary healthcare level. Technical Report. Sheffield, UK: WHO Collaborating Centre for Metabolic Bone Disease, University of Sheffield; 2008; Available at
  • 8
    Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E. FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int. 2008; 19: 38597.
  • 9
    Donaldson MG, Palermo L, Schousboe JT, Ensrud KE, Hochberg MC, Cummings SR. FRAX and risk of vertebral fractures: the fracture intervention trial. J Bone Miner Res. 2009; 24: 17939.
  • 10
    Ensrud KE, Lui LY, Taylor BC, Schousboe JT, Donaldson MG, Fink HA, Cauley JA, Hillier TA, Browner WS, Cummings SR. Study of Osteoporotic Fractures Research Group. A comparison of prediction models for fractures in older women: is more better?. Arch Intern Med. 2009; 169: 208794.
  • 11
    Hippisley-Cox J, Coupland C. Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScores. BMJ. 2009; 339: 12915.
  • 12
    Leslie WD, Lix LM, Johansson H, Oden A, McCloskey E, Kanis JA. Independent clinical validation of a Canadian FRAX tool: fracture prediction and model calibration. J Bone Miner Res. 2009; 25: 23508.
  • 13
    Pluskiewicz W, Adamczyk P, Franek E, Leszczynski P, Sewerynek E, Wichrowska H, Napiorkowska L, Kostyk T, Stuss M, Stepien-Klos W, Golba KS, Drozdzowska B. Ten-year probability of osteoporotic fracture in 2012 Polish women assessed by FRAX and nomogram by Nguyen et al. Conformity between methods and their clinical utility. Bone. 2010; 46: 16617.
  • 14
    Sandhu SK, Nguyen ND, Center JR, Pocock NA, Eisman JA, Nguyen TV. Prognosis of fracture: evaluation of predictive accuracy of the FRAX algorithm and Garvan nomogram. Osteoporos Int. 2010; 21: 86371.
  • 15
    Tremollieres FA, Pouilles JM, Drewniak N, Laparra J, Ribot CA, Dargent-Molina P. Fracture risk prediction using BMD and clinical risk factors in early postmenopausal women: sensitivity of the WHO FRAX tool. J Bone Miner Res. 2010; 25: 10029.
  • 16
    Tanaka S, Yoshimura N, Kuroda T, Hosoi T, Saito M, Shiraki M. The Fracture and Immobilization Score (FRISC) for risk assessment of osteoporotic fracture and immobilization in postmenopausal women—a joint analysis of the Nagano, Miyama, and Taiji Cohorts. Bone. 2010; 47: 106470.
  • 17
    Cummins NM, Poku EK, Towler MR, O'Driscoll OM, Ralston SH. Clinical risk factors for osteoporosis in Ireland and the UK: a comparison of FRAX and QFracture Scores. Calcif Tissue Int. 2011; 89: 1727.
  • 18
    Fraser LA, Langsetmo L, Berger C, Ioannidis G, Goltzman D, Adachi JD, Papaioannou A, Josse R, Kovacs CS, Olszynski WP, Towheed T, Hanley DA, Kaiser SM, Prior J, Jamal S, Kreiger N, Brown JP, Johansson H, Oden A, McCloskey E, Kanis JA, Leslie WD. CaMos Research Group. Fracture prediction and calibration of a Canadian FRAX tool: a population-based report from CaMos. Osteoporos Int. 2011; 22: 82937.
  • 19
    Bolland MJ, Siu AT, Mason BH, Horne AM, Ames RW, Grey AB, Gamble GD, Reid IR. Evaluation of the FRAX and Garvan fracture risk calculators in older women. J Bone Miner Res. 2011; 26: 4207.
  • 20
    Sambrook PN, Flahive J, Hooven FH, Boonen S, Chapurlat R, Lindsay R, Nguyen TV, Díez-Perez A, Pfeilschifter J, Greenspan SL, Hosmer D, Netelenbos JC, Adachi JD, Watts NB, Cooper C, Roux C, Rossini M, Siris ES, Silverman S, Saag KG, Compston JE, LaCroix A, Gehlbach S. Predicting fractures in an international cohort using risk factor algorithms, without bone mineral density. J Bone Miner Res. 2011; 26: 27707.
  • 21
    Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA. 2010; 303(3): 23541.
  • 22
    Finucane MM, Stevens GA, Cowan MJ, et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet. 2011; 377(9765): 55767.
  • 23
    Cummings SR, Black DM, Nevitt MC, Browner WS, Cauley JA, Genant HK, Mascioli SR, Scott JC, Seeley DG, Steiger P. the Study of Osteoporotic Fractures Research Group. Appendicular bone density and age predict hip fracture in women. JAMA. 1990; 263: 6658.
  • 24
    Steiger P, Cummings SR, Black DM, Spencer NE, Genant HK. Age-related decrements in bone mineral density in women over 65. J Bone Miner Res. 1992; 7: 62532.
  • 25
    Ensrud KE, Palermo L, Black DM, Cauley J, Jergas M, Orwoll ES, Nevitt MC, Fox KM, Cummings SR. Hip and calcaneal bone loss increase with advancing age: longitudinal results from the study of osteoporotic fractures. J Bone Miner Res. 1995; 10: 177887.
  • 26
    Hillier TA, Cauley JA, Rizzo JH, Pedula KL, Ensrud KE, Bauer DC, Lui LY, Vesco KK, Black DM, Donaldson MG, Leblanc ES, Cummings SR. WHO absolute fracture risk models (FRAX): do clinical risk factors improve fracture prediction in older women without osteoporosis?. J Bone Miner Res. 2011; 26: 177482.
  • 27
    Donaldson MG, Cawthon PM, Schousboe JT, Ensrud KE, Lui LY, Cauley JA, Hillier TA, Taylor BC, Hochberg MC, Bauer DC, Cummings SR. Study of Osteoporotic Fractures (SOF). Novel methods to evaluate fracture risk models. J Bone Miner Res. 2011; 26: 176773.
  • 28
    National Osteoporosis Foundation. Physician's guide to prevention and treatment of osteoporosis. Washington, DC: National Osteoporosis Foundation; 2008.
  • 29
    Vickers AJ, Elkin EB. Decision curve analysis: a novel method for evaluating prediction models. Med Decis Making. 2006; 26: 56574.
  • 30
    Steyerberg EW, Vickers AJ. Decision curve analysis: a discussion. Med Decis Making. 2008; 28: 1469.
  • 31
    Vickers AJ. Decision analysis for the evaluation of diagnostic tests, prediction models and molecular markers. Am Stat. 2008; 62: 31420.
  • 32
    Premaor MO, Ensrud K, Lui L, Parker RA, Cauley J, Hillier TA, Cummings S, Compston JE. Study of Osteoporotic Fractures. Risk factors for nonvertebral fracture in obese older women. J Clin Endocrinol Metab. 2011; 96: 241421.
  • 33
    Johansson H, Kanis JA, Oden A, McCloskey EV, Chapurlat R, Christiansen C, Cummings S, Diez-Perez A, Eisman J, Fujiwara S, Gluer C-C, Hans D, Khaw KT, Krieg M-A, Kroger H, La Croix A, Lau E, Leslie W, Mellstrom D, Melton LJ, O'Neill T, Pasco J, Prior J, Reid D, Rivadeneira F, Torgerson D, van Staa T, Yoshimura N, Zillikens M. High body mass index, adjusted for BMD, is a risk factor for fracture in women. ASBMR 2011 Abstract no. 1026.