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Bone mineral content and density of the lumbar spine of infants and toddlers: Influence of age, sex, race, growth, and human milk feeding

  1. Heidi J Kalkwarf1,*,
  2. Babette S Zemel2,
  3. Kimberly Yolton1,
  4. James E Heubi3

Article first published online: 18 DEC 2012

DOI: 10.1002/jbmr.1730

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 28, Issue 1, pages 206–212, January 2013

Additional Information

How to Cite

Kalkwarf, H. J., Zemel, B. S., Yolton, K. and Heubi, J. E. (2013), Bone mineral content and density of the lumbar spine of infants and toddlers: Influence of age, sex, race, growth, and human milk feeding. J Bone Miner Res, 28: 206–212. doi: 10.1002/jbmr.1730

Author Information

  1. 1

    Division of General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA

  2. 2

    Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA

  3. 3

    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA

*Division of General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.

Publication History

  1. Issue published online: 18 DEC 2012
  2. Article first published online: 18 DEC 2012
  3. Accepted manuscript online: 8 AUG 2012 11:21AM EST
  4. Manuscript Accepted: 23 JUL 2012
  5. Manuscript Revised: 20 JUL 2012
  6. Manuscript Received: 29 MAR 2012

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References

  • 1
    Salle BL, Braillon P, Glorieux FH, Brunet J, Cavero E, Meunier PJ. Lumbar bone mineral content measured by dual energy-xray absorptiometry in newborns and infants. Acta Paediatr. 1992; 81: 953–8.
    Direct Link:
  • 2
    Kurl S, Heinonen K, Jurvelin JS, Lansimies E. Lumbar bone mineral content and density measured using a Lunar DPX densitometer in healthy full-term infants during the first year of life. Clin Physiol Func Imaging. 2002; 22: 222–5.
    Direct Link:
  • 3
    Unal A, Gur E, Arvas A, Erginel A, Alikasifoglu M, Ilter O. Bone density values in healthy Turkish infants. Indian Pediatr. 2000; 37: 497–503.
  • 4
    Ellis KJ. Body composition of a young, multiethnic, male population. Am J Clin Nutr. 1997; 66: 1323–31.
  • 5
    Ellis KJ, Abrams SA, Wong WW. Body composition of a young, multiethnic female population. Am J Clin Nutr. 1997; 65: 724–31.
  • 6
    Bachrach LK, Hastie T, Wang M-C, Narasimhan B, Marcus R. Bone mineral acquisition in healthy Asian, Hispanic, Black and Caucasian youth: a longitudinal study. J Clin Endocrinol Metab. 1999; 84(12): 4702–12.
  • 7
    Kalkwarf HJ, Zemel BS, Gilsanz V, Lappe JM, Horlick M, Oberfield S, Mahboubi S, Fan B, Frederick MM, Winer K, Shepherd JA. The bone mineral density in childhood study: bone mineral content and density according to age, sex, and race. J Clin Endocrinol Metab. 2007; 92: 2087–99.
  • 8
    McCormick DP, Ponder SW, Fawcett HD, Palmer JL. Spinal bone mineral density in 335 normal and obese children and adolescents: evidence for ethnic and sex differences. J Bone Miner Res. 1991; 6(5): 507–13.
    Direct Link:
  • 9
    Nelson DA, Simpson PM, Johnson CC, Barondess DA, Kleerekoper M. The accumulation of whole body skeletal mass in third- and fourth-grade children: effects of age, gender, ethnicity, and body composition. Bone. 1997; 20: 73–8.
  • 10
    Zemel BS, Leonard MB, Kelly A, Lappe JM, Gilsanz V, Oberfield S, Mahboubi S, Shepherd JA, Hangartner T, Frederick MM, Winer K, Kalkwarf HJ. Height adjustment in assessing dual energy x-ray absorptiometry measurements of bone mass and density in children. J Clin Endocrinol Metab. 2010; 95: 1265–73.
  • 11
    Dewey KG, Heinig ML, Nommsen LA, Peerson JM, Lonnerdal B. Growth of breast-fed and formula-fed infants from 0 to 18 months: the DARLING study. Pediatrics. 1992; 89: 1036–41.
  • 12
    Frankenburg WK, Dodds J, Archer P, Bresnick B, Maschka P, Edelman N, Shapiro H. DENVER II training manual. 2nd ed. Denver, CO: Denver Developmentals Materials; 1992.
  • 13
    Roche AF, Davila GH. Differences between recumbent length and stature within individuals. Growth. 1974; 38: 313–20.
  • 14
    Cole T, Pan H, program LMS. version 1.16. Compiled 15 April 2002.
  • 15
    Cole TJ, Green PJ. Smoothing reference centile curves: the lms method and penalized likelihood. Stat Med. 1992; 11(10): 1305–19.
    Direct Link:
  • 16
    Gluer CC, Blake G, Lu Y, Blunt BA, Jergas M, Genant HK. Accurate assessment of precision errors: how to measure the reproducibility of bone densitometry techniques. Osteoporosis Int. 1995; 5: 262–70.
  • 17
    Nelson DA, Koo WWK. Interpretation of absorptiometric bone mass measurements in the growing skeleton: issues and limitations. Calcif Tissue Int. 1999; 65(1): 1–3.
  • 18
    Shepherd JA, Wang L, Fan B, Gilsanz V, Kalkwarf HJ, Lappe JM, Lu Y, Hangartner T, Zemel BS, Fredrick M, Oberfield S, Winer KK. Optimal monitoring time interval between DXA measures in children. J Bone Miner Res. 2011; 26: 2745–52.
    Direct Link:
  • 19
    Gordon CM, Bachrach LK, Carpenter TO, Crabtree N, El-Hajj Fuleihan G, Kutilek S, Lorenc RS, Tosi LL, Ward KA, Ward LM, Kalkwarf HJ. Dual energy x-ray absorptiometry interpretation and reporting in children and adolescents: the 2007 ISCD pediatric official positions. J Clin Densitom. 2008; 11: 43–58.
  • 20
    Clark E, Ness AR, Bishop NJ, Tobias JH. Association between bone mass and fractures in children: a prospective cohort study. J Bone Miner Res. 2006; 21: 1489–95.
    Direct Link:
  • 21
    Goulding A, Cannan R, Williams SM, Gold EJ, Taylor RW, Lewis-Barned NJ. Bone mineral density in girls with forearm fractures. J Bone Miner Res. 1998; 13(1): 143–8.
    Direct Link:
  • 22
    Goulding A, Jones IE, Taylor RW, Williams SM, Manning PJ. Bone mineral density and body composition in boys with distal forearm fractures: a dual-energy x-ray absorptiometry study. J Pediatr. 2001; 139(4): 509–15.
  • 23
    Kalkwarf HJ, Laor T, Bean J. Fracture risk in children with a forearm injury is associated with volumetric bone density and cortical area (by peripheral QCT) and areal bone density (by DXA). Osteoporos Int. 2011; 22: 607–16.
  • 24
    Gafni RI, Baron J. Childhood bone mass acquisition and peak bone mass may not be important determinants of bone mass in late adulthood. Pediatrics. 2007; 119(Suppl 2): S131–6.
  • 25
    Hammami M, Koo WW, Hockman EM. Body composition of neonates from fan beam dual energy X-ray absorptiometry measurement. JPEN J Parenter Enteral Nutr. 2003; 27(6): 423–6.
  • 26
    Koo WW, Bush AJ, Walters J, Carlson SE. Postnatal development of bone mineral status during infancy. J Am Coll Nutr. 1998; 17(1): 65–70.
  • 27
    Rupich RC, Specker BL, Lieuw AFM, Ho M. Gender and race differences in bone mass during infancy. Calcif Tissue Int. 1996; 58(6): 395–7.
  • 28
    Prentice A, Laskey A, Shaw J, Cole TJ, Fraser DR. Bone mineral content of Gambian and British children aged 0–36 months. Bone Miner. 1990; 10: 211–24.
  • 29
    Li J-Y, Specker BL, Ho M, Tsang RC. Bone mineral content in black and white children 1 to 6 years of age: early appearance of race and sex differences. AJDC. 1989; 143: 1346–9.
  • 30
    Zemel BS, Kalkwarf HJ, Gilsanz V, Lappe JM, Oberfield S, Shepherd JA, Frederick MM, Huang X, Lu M, Mahboubi S, Hangartner T, Winer KK. Revised reference curves for bone mineral content and areal bone mineral density according to age and sex for black and non-black children: results of the bone mineral density in childhood study. J Clin Endocrin Metab. 2011; 96: 3160–9.
  • 31
    Specker BL, Beck A, Kalkwarf H, Ho M. Randomized trial of varying mineral intake on total body bone mineral accretion during the first year of life. Pediatrics. 1997; 99(6): E12.
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