Original Article

DNA damage drives accelerated bone aging via an NF-κB–dependent mechanism

  1. Qian Chen1,
  2. Kai Liu2,
  3. Andria R Robinson3,4,
  4. Cheryl L Clauson4,5,
  5. Harry C Blair6,7,
  6. Paul D Robbins4,5,†,
  7. Laura J Niedernhofer4,5,
  8. Hongjiao Ouyang1,8,9,10,*

Article first published online: 17 APR 2013

DOI: 10.1002/jbmr.1851

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 28, Issue 5, pages 1214–1228, May 2013

Additional Information

How to Cite

Chen, Q., Liu, K., Robinson, A. R., Clauson, C. L., Blair, H. C., Robbins, P. D., Niedernhofer, L. J. and Ouyang, H. (2013), DNA damage drives accelerated bone aging via an NF-κB–dependent mechanism. J Bone Miner Res, 28: 1214–1228. doi: 10.1002/jbmr.1851

Author Information

  1. 1

    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

  2. 2

    Department of Oral Biology, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, USA

  3. 3

    Department of Human Genetics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA

  4. 4

    University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA

  5. 5

    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

  6. 6

    Pittsburgh Veteran's Affairs Medical Center, Pittsburgh, PA, USA

  7. 7

    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

  8. 8

    Department of Restorative Dentistry and Comprehensive Care, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, USA

  9. 9

    Center for Craniofacial Regeneration, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, USA

  10. 10

    McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA

  1. †

    7 Paul D Robbins and Laura J Niedernhofer, Department of Metabolism and Aging, Scripps Florida, Jupiter, FL 33458, USA.

*Department of Restorative Dentistry and Comprehensive Care, University of Pittsburgh School of Dental Medicine, 630 Salk Hall 3550 Terrace Street, Pittsburgh, PA 15261, USA.

Publication History

  1. Issue published online: 17 APR 2013
  2. Article first published online: 17 APR 2013
  3. Accepted manuscript online: 21 DEC 2012 10:58AM EST
  4. Manuscript Accepted: 26 NOV 2012
  5. Manuscript Revised: 15 NOV 2012
  6. Manuscript Received: 17 APR 2012

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