KW and CC are joint senior authors.
Growth From Birth to Adulthood and Bone Phenotype in Early Old Age: A British Birth Cohort Study
Article first published online: 19 DEC 2013
© 2014 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Journal of Bone and Mineral Research
Volume 29, Issue 1, pages 123–133, January 2014
How to Cite
Kuh, D., Wills, A. K., Shah, I., Prentice, A., Hardy, R., Adams, J. E., Ward, K., Cooper, C. and National Survey for Health and Development (NSHD) Scientific and Data Collection Team (2014), Growth From Birth to Adulthood and Bone Phenotype in Early Old Age: A British Birth Cohort Study. J Bone Miner Res, 29: 123–133. doi: 10.1002/jbmr.2008
- Issue published online: 19 DEC 2013
- Article first published online: 19 DEC 2013
- Accepted manuscript online: 12 JUN 2013 08:05AM EST
- Manuscript Accepted: 3 JUN 2013
- Manuscript Revised: 21 MAY 2013
- Manuscript Received: 14 NOV 2012
- MRC. Grant Numbers: U1200632239, U123092720, U105960371
- growth trajectory;
- bone strength;
- bone area;
There is growing evidence that early growth influences bone mass in later life but most studies are limited to birth weight and/or early infant growth and dual-energy X-ray absorptiometry (DXA) measurements. In a British birth cohort study with prospective measures of lifetime height and weight, we investigated the growth trajectory in relation to bone in males (M) and females (F) at 60 to 64 years old. Outcomes were DXA measures of hip and spine areal bone density (aBMD) (n = 1658) and pQCT measures of distal and diaphyseal radius cross-sectional area (CSA), strength, and volumetric bone density (vBMD) (n = 1350 of the 1658). Regression models examined percentage change in bone parameters with standardized measures of birth weight, height, and weight. A series of conditional growth models were fitted for height and weight gain (using intervals: birth–2, 2–4, 4–7, 7–15, 15–20, 20–36, and 36–64 years) and height gain (using intervals: 2–4, 4–7, 7–15, and 15–36 years). Birth weight was positively related to bone CSA (M: 1.4%; 95% confidence interval [CI], 0.3%–2.5%; F: 1.3%; 95% CI, 0.3%–2.4% per 1 SD increase in birth weight for diaphyseal CSA) and strength (M: 1.8%; 95% CI, 0.3–3.4; F: 2.0%; 95% CI, 0.5–3.5). No positive associations were found with trabecular, total, or cortical vBMD. One SD change in prepubertal and postpubertal height and weight velocities were associated with between 2% and 5% greater bone CSA and strength. Height gain in later years was negatively associated with trabecular vBMD. Weight gain velocity during the adult years was positively associated with up to 4% greater trabecular and total BMD, and 4% greater aBMD at hip and spine. In a cohort born in the early post-war period, higher birth weight, gaining weight and height faster than others, particularly through the prepubertal and postpubertal periods, was positively related to bone strength, mostly through greater bone CSA, at 60 to 64 years. © 2014 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research.