Additional Supporting Information may be found in the online version of this article.


Figure S1. Generation and confirmation of a floxed Rankl allele.

Figure S2. Bone phenotype of mice with T cell–specific inactivation of Rankl.

Figure S3. Mice with osteoblast lineage–specific deficiency of RANKL are partially protected from osteoclastogenesis in K/B×N model.

Figure S4. Mice with T cell–specific deficiency of RANKL are not protected from the development of RA.

Figure S5. Gene expression in osteoblast- and osteocyte-rich fractions.

Table S1. Oligonucleotide primers for qPCR.

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