BW and XL contributed equally to this work.
Perlecan-Containing Pericellular Matrix Regulates Solute Transport and Mechanosensing Within the Osteocyte Lacunar-Canalicular System
Article first published online: 19 MAR 2014
© 2014 American Society for Bone and Mineral Research
Journal of Bone and Mineral Research
Volume 29, Issue 4, pages 878–891, April 2014
How to Cite
Wang, B., Lai, X., Price, C., Thompson, W. R., Li, W., Quabili, T. R., Tseng, W.-J., Liu, X. S., Zhang, H., Pan, J., Kirn-Safran, C. B., Farach-Carson, M. C. and Wang, L. (2014), Perlecan-Containing Pericellular Matrix Regulates Solute Transport and Mechanosensing Within the Osteocyte Lacunar-Canalicular System. J Bone Miner Res, 29: 878–891. doi: 10.1002/jbmr.2105
- Issue published online: 19 MAR 2014
- Article first published online: 19 MAR 2014
- Accepted manuscript online: 24 SEP 2013 08:47AM EST
- Manuscript Accepted: 19 SEP 2013
- Manuscript Revised: 13 SEP 2013
- Manuscript Received: 23 JUL 2013
- NIH. Grant Numbers: AR054385, P30GM103333, AR064133, P01CA098912, P30AR050950, P20RR016458
- Central Universities, China. Grant Number: CDJXS12232258
- CSC Fellowship of China
- China CSC Scholarship
Additional Supporting Information may be found in the online version of this article.
Supplemental Fig. 1S Optically measured tibial surface strains (measured on the anterior-posterior surface 25–50% distal from the proximal end) as a function of the axially applied loads. No significant difference in the mean compliance of the tibiae was detected between the 8–9 month-old CTL and perlecan-deficient (Hypo) mice (CTL: y = 101.9x, R2 = 0.93; Hypo: y = 96.1x, R2 = 0.99). Thus, the same 3N peak load was applied to both genotypes during FRAP experiments.
Supplemental Table 1S Results of µCT imaging, mechanical testing, and dynamic bone labeling analysis at the tibial mid-diaphysis of 3.5 month-old CTL and Hypo mice
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