Additional Supporting Information may be found in the online version of this article.


Supplementary Fig 1. Image of the OsteoProbe® Reference Point Indenter (Active Life Scientific Inc., Santa Barbara, CA), a hand-held microindentation instrument designed for in vivo measurements of bone material strength (BMS) in humans at the midshaft of the non-dominant anterior tibia.

Supplementary Fig 2. Time (s; seconds) versus force (N; newtons) plot showing a single OsteoProbe® measurement cycle including the four basic operations of the device: (1) pre-load, (2) trigger, (3) impact, (4) unloading. Reproduced from Bridges et al. (Rev Sci Instrum 2012;83:044301) with permission.

Supplementary Table 1. Medications of the patients with type 2 diabetes and age-matched, non-diabetic controls.

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