Additional Supporting Information may be found in the online version of this article.


Supplemental Fig. S1. CONSORT diagram outlining the flow of the study subjects (boys and girls) through all stages of the randomized clinical trial.

Supplemental Fig. S2. Box plots showing the distribution of 25(OH) D levels in the low and high dose treatment groups, in the overall group, and by gender, based on their 25(OH)D levels at baseline and at 12 months. Solid lines inside each box plot represent the median, and the bold dotted lines the mean level for serum 25(OH)D. The lower margin of the boxplot represents the 25th percentile, the upper margin is the 75th percentile, and the lower and upper whiskers represent the 10th and 90th percentile respectively. Dashed lines represent the predefined cutoff levels of 25(OH)D levels. i.e. 20 ng/ml and 30 ng/ml. p-values represent levels of significance between baseline and 12 months using paired t-tests, except for * representing Wilcoxon Signed Rank Test.

Supplemental Fig. S3. Proportion of subjects with serum 25(OH)D at or above 20 ng/ml and 30 ng/ml in Low Dose (200 IU/day) and High Dose (2000 IU/day) treatment groups at baseline and 12 months of Vitamin D3 supplementation by gender. Numbers in parentheses represent the actual percentages in each group at baseline and 12 months of Vitamin D3 supplementation. p-values represent significance level using McNemar Test. p = NS (Not Significant) represents p-values > 0.05.

Supplemental Table S1: Pediatric Normative ranges for biochemical and hormonal values reported in the study

Supplemental Table S2: Biochemical baseline characteristics of study sample. Mean ± SD, Median (25th–75th Quartile)

Supplemental Table S3: Effect of Vitamin D3 supplementation on proportion of children reaching levels above predefined cutoffs by treatment groups and pubertal stages within same gender.

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