An atypical subtrochanteric femoral fracture from pycnodysostosis: A lesson from nature

Authors

  • Christopher J Yates,

    1. Endocrinology Unit, University of Melbourne, Western Hospital, Footscray, Victoria, Australia
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  • Miriam J Bartlett,

    1. Endocrinology Unit, University of Melbourne, Western Hospital, Footscray, Victoria, Australia
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  • Peter R Ebeling

    Corresponding author
    1. Endocrinology Unit, University of Melbourne, Western Hospital, Footscray, Victoria, Australia
    2. Department of Medicine, University of Melbourne, Western Hospital, Footscray, Victoria, Australia
    • Department of Medicine, University of Melbourne, Western Hospital, Gordon Street, Footscray, Victoria 03011, Australia.
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Abstract

This case describes a man with an unusual cause of an atypical subtrochanteric fracture, pycnodysostosis. This condition results from mutations involving the cathepsin K gene. New antiresorptive treatments for osteoporosis inhibit the cathepsin K enzyme in osteoclasts. Therefore, there should be vigilant monitoring for the development of long-term complications noted to occur in diseases of reduced osteoclast function, including pycnodysostosis, in patients receiving these novel antiresorptive agents. © 2011 American Society for Bone and Mineral Research.

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