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Keywords:

  • Chip-Chip Analysis;
  • Chip-Seq Analysis;
  • RNA-Seq Analysis;
  • Transcription;
  • Epigenome;
  • Histone Modification;
  • Distal Regulation;
  • Coregulators;
  • RNA Polymerase;
  • Bacterial Artificial Chromosomes (BAC);
  • Transgenic Mice

Abstract

The regulation of gene expression represents one of the most fundamental of biologic processes that controls cellular proliferation, differentiation, and function. Recent technological advances in genome-wide annotation together with bioinformatic/computational analyses have contributed significantly to our understanding of transcriptional regulation at the epigenomic and regulomic levels. This perspective outlines the techniques that are being utilized and summarizes a few of the outcomes. © 2011 American Society for Bone and Mineral Research.