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Perspective
Genome-scale techniques highlight the epigenome and redefine fundamental principles of gene regulation
Article first published online: 24 MAY 2011
DOI: 10.1002/jbmr.317
Copyright © 2011 American Society for Bone and Mineral Research
Additional Information
How to Cite
Pike, J. W. (2011), Genome-scale techniques highlight the epigenome and redefine fundamental principles of gene regulation. J Bone Miner Res, 26: 1155–1162. doi: 10.1002/jbmr.317
Publication History
- Issue published online: 24 MAY 2011
- Article first published online: 24 MAY 2011
- Accepted manuscript online: 16 DEC 2010 07:17AM EST
- Manuscript Accepted: 1 DEC 2010
- Manuscript Revised: 15 NOV 2010
- Manuscript Received: 23 AUG 2010
- Abstract
- Article
- References
- Cited By
Keywords:
- Chip-Chip Analysis;
- Chip-Seq Analysis;
- RNA-Seq Analysis;
- Transcription;
- Epigenome;
- Histone Modification;
- Distal Regulation;
- Coregulators;
- RNA Polymerase;
- Bacterial Artificial Chromosomes (BAC);
- Transgenic Mice
Abstract
The regulation of gene expression represents one of the most fundamental of biologic processes that controls cellular proliferation, differentiation, and function. Recent technological advances in genome-wide annotation together with bioinformatic/computational analyses have contributed significantly to our understanding of transcriptional regulation at the epigenomic and regulomic levels. This perspective outlines the techniques that are being utilized and summarizes a few of the outcomes. © 2011 American Society for Bone and Mineral Research.