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Circulating osteogenic cells: Implications for injury, repair, and regeneration

  1. Robert J Pignolo1,*,
  2. Moustapha Kassem2,3

Article first published online: 2 MAY 2011

DOI: 10.1002/jbmr.370

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 26, Issue 8, pages 1685–1693, August 2011

Additional Information

How to Cite

Pignolo, R. J. and Kassem, M. (2011), Circulating osteogenic cells: Implications for injury, repair, and regeneration. J Bone Miner Res, 26: 1685–1693. doi: 10.1002/jbmr.370

Author Information

  1. 1

    Departments of Medicine and Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

  2. 2

    Department of Endocrinology and Metabolism, University Hospital of Odense, Odense, Denmark

  3. 3

    Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Saudi Arabia

*Departments of Medicine & Orthopaedic Surgery, University of Pennsylvania School of Medicine, 424B Stemmler Hall, 36th Street & Hamilton Walk, Philadelphia, PA 19104-6081, USA.

Publication History

  1. Issue published online: 20 JUL 2011
  2. Article first published online: 2 MAY 2011
  3. Manuscript Accepted: 9 FEB 2011
  4. Manuscript Revised: 28 JAN 2011
  5. Manuscript Received: 7 NOV 2010

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Keywords:

  • MESENCHYMAL STEM CELLS;
  • BLOOD;
  • CIRCULATING OSTEOGENIC PRECURSOR CELLS;
  • FRACTURE;
  • HETEROTOPIC OSSIFICATION

Abstract

The aim of this review is to provide a critical reading of recent literature pertaining to the presence of circulating, fluid-phase osteoblastic cells and their possible contribution to bone formation. We have termed this group of cells collectively as circulating osteogenic precursor (COP) cells. We present evidence for their existence, methods used for their isolation and identification, possible physiological and pathophysiological roles, cellular origins, and possible mechanisms for their migration to target tissues. © 2011 American Society for Bone and Mineral Research

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