Original Article

Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes

  1. Jasmin Divers1,
  2. Thomas C Register2,
  3. Carl D Langefeld1,
  4. Lynne E Wagenknecht1,
  5. Donald W Bowden3,4,5,
  6. J Jeffrey Carr1,6,
  7. R Caresse Hightower6,
  8. Jianzhao Xu5,
  9. Keith A Hruska7,
  10. Barry I Freedman8,*

Article first published online: 21 JUN 2011

DOI: 10.1002/jbmr.389

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 26, Issue 7, pages 1554–1560, July 2011

Additional Information

How to Cite

Divers, J., Register, T. C., Langefeld, C. D., Wagenknecht, L. E., Bowden, D. W., Carr, J. J., Hightower, R. C., Xu, J., Hruska, K. A. and Freedman, B. I. (2011), Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes. J Bone Miner Res, 26: 1554–1560. doi: 10.1002/jbmr.389

Author Information

  1. 1

    Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA

  2. 2

    Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA

  3. 3

    Endocrinology, Wake Forest University School of Medicine, Winston-Salem, NC, USA

  4. 4

    Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA

  5. 5

    Centers for Diabetes Research and Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA

  6. 6

    Radiologic Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA

  7. 7

    Department of Pediatrics, Medicine and Cell Biology, Washington University School of Medicine, St Louis, MO, USA

  8. 8

    Nephrology, Wake Forest University School of Medicine, Winston-Salem, NC, USA

*Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1053, USA.

Publication History

  1. Issue published online: 21 JUN 2011
  2. Article first published online: 21 JUN 2011
  3. Accepted manuscript online: 24 MAR 2011 09:11AM EST
  4. Manuscript Accepted: 10 MAR 2011
  5. Manuscript Revised: 28 FEB 2011
  6. Manuscript Received: 21 JAN 2011

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Keywords:

  • African americans;
  • Atherosclerosis;
  • Calcified plaque;
  • Bone mineral density;
  • Diabetes mellitus;
  • Osteoporosis

Abstract

Inverse relationships have been reported between bone mineral density (BMD) and calcified atherosclerotic plaque (CP). This suggests these processes may be related. We examined relationships between BMD and CP in 753 African Americans with type 2 diabetes from 664 families, accounting for the effects of modifiable cardiovascular disease (CVD) risk factors. Association analyses were performed using generalized estimating equations (GEEs) to assess cross-sectional relationships between computed tomography–determined measures of thoracic and lumbar vertebral volumetric BMD (vBMD) and CP in the coronary and carotid arteries and infrarenal aorta. Significant inverse associations were seen between thoracic and lumbar vBMD and CP in all three vascular beds in unadjusted analyses. A fully adjusted model accounting for age, sex, body mass index, systolic blood pressure, low-density lipoprotein cholesterol, C-reactive protein, hemoglobin A1c, smoking, and hormone-replacement therapy revealed significant inverse associations between thoracic vBMD and CP in coronary and carotid arteries and aorta, whereas lumbar vBMD was associated with CP in coronary artery and aorta. Inverse associations exist between vertebral BMD and calcified atherosclerotic plaque in African-American men and women with type 2 diabetes. This relationship was independent of conventional CVD risk factors and supports the hypothesis that bone metabolism and atherosclerotic plaque mineralization are related processes. © 2011 American Society for Bone and Mineral Research.

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