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Original Article
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Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis
Article first published online: 21 SEP 2011
DOI: 10.1002/jbmr.460
Copyright © 2011 American Society for Bone and Mineral Research
1523-4681/asset/cover.gif?v=1&s=a8419ff5f302b0d9fefec557d81c0aa9776c60e3 "Journal of Bone and Mineral Research")
Additional Information
How to Cite
Tseng, P.-C., Hou, S.-M., Chen, R.-J., Peng, H.-W., Hsieh, C.-F., Kuo, M.-L. and Yen, M.-L. (2011), Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis. J Bone Miner Res, 26: 2552–2563. doi: 10.1002/jbmr.460
Publication History
- Issue published online: 21 SEP 2011
- Article first published online: 21 SEP 2011
- Accepted manuscript online: 28 JUN 2011 09:13AM EST
- Manuscript Accepted: 20 JUN 2011
- Manuscript Revised: 26 MAY 2011
- Manuscript Received: 14 OCT 2010
References
- 1. Estrogen research: the great estrogen conundrum. Science. 2003;302:1136–38.
- 2, , , . Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Natl Acad Sci USA. 1997;94:14138–43.
- 3, , , . Effects of diverse dietary phytoestrogens on cell growth, cell cycle and apoptosis in estrogen-receptor-positive breast cancer cells. J Nutr Biochem. 2010;21:856–64.
- 4, . Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: protection against oxidative and electrophilic injury. Eur J Pharmacol. 2004;489:39–48.
- 5, , , , . Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. J Biol Chem. 2007;282:19385–98.
- 6. Dietary polyphenols mediated regulation of oxidative stress and chromatin remodeling in inflammation. Nutr Rev. 2008;66 (Suppl 1): S42–45.
- 7, , , , , , , , , , , . Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003;425:191–6.
- 8, . Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases. Nutr Rev. 2008;66:591–6.
- 9, , , , , , . Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation. Phytomedicine. 2007;14:806–14.
- 10, , , . Resveratrol attenuates ovariectomy-induced hypertension and bone loss in stroke-prone spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo). 2000;46:78–83.
- 11, , , . Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells. Cells Tissues Organs. 2009;189:93–7.
- 12, , , , , , , , , . Resveratrol augments the canonical Wnt signaling pathway in promoting osteoblastic differentiation of multipotent mesenchymal cells. Exp Cell Res. 2009;315:2953–62.
- 13, , , , , . Resveratrol prevents CsA inhibition of proliferation and osteoblastic differentiation of mouse bone marrow-derived mesenchymal stem cells through an ER/NO/cGMP pathway. Toxicol In Vitro. 2006;20:915–22.
- 14, . Mammalian sirtuins–emerging roles in physiology, aging, and calorie restriction. Genes Dev. 2006;20:2913–21.
- 15, , , , , , , , , , , , , , , , , , , , , , , , , , , . Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007;450:712–16.
- 16, , , , , , , . Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell. 2001;107:137–48.
- 17, , , , , , , . hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell. 2001;107:149–59.
- 18, , , , , , , , , , , , , , , , . Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science. 2004;303:2011–15.
- 19, , , , , , , , . SIRT1 promotes DNA repair activity and deacetylation of Ku70. Exp Mol Med. 2007;39:8–13.
- 20, , , , , , . Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 2004;23:2369–80.
- 21, , . Neurogenesis directed by Sirt1. Nat Cell Biol. 2008;10:373–4.
- 22, , , , , , , , , , , , , , , , , , . SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a. FEBS Lett. 2009;583:1183–8.
- 23, . FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene. 2005;24:7410–25.
- 24, . Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol. 2007;8:440–50.
- 25, , . Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins. Cell Cycle. 2005;4:908–13.
- 26, , , . Suppression of PPAR transactivation switches cell fate of bone marrow stem cells from adipocytes into osteoblasts. Ann N Y Acad Sci. 2007;1116:182–95.
- 27, . Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways. J Cell Biochem. 2003;88:446–54.
- 28. Regulation of osteoblast differentiation by transcription factors. J Cell Biochem. 2006;99:1233–9.
- 29, , , , , . PPARγ2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells. J Cell Biochem. 2009;106:232–46.
- 30, , , , , , , , . Sirt1 promotes fat mobilization in white adipocytes by repressing PPARγ. Nature. 2004;429:771–6.
- 31, , , , , , , . Activation of peroxisome proliferator-activated receptor-gamma inhibits the Runx2-mediated transcription of osteocalcin in osteoblasts. J Biol Chem. 2003;278:23270–7.
- 32, , . Transcriptional regulation of the human Runx2/Cbfa1 gene promoter by bone morphogenetic protein-7. Mol Cell Endocrinol. 2003;205:121–9.
- 33, , , , , . Unique gene expression signatures of independently-derived human embryonic stem cell lines. Hum Mol Genet. 2004;13:601–8.
- 34, , , , , , , . DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science. 2002;296:530–4.
- 35, , , , , , , , , , . Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest. 2010;120:545–58.
- 36, , , , , , . Brief report: Human embryonic stem cell-derived mesenchymal progenitors possess strong immunosuppressive effects toward natural killer cells as well as T lymphocytes. Stem Cells. 2009;27:451–6.
- 37, , , . Derivation of multipotent mesenchymal precursors from human embryonic stem cells. PLoS Med. 2005;2:e161.
- 38, , . Differentiation of human embryonic stem cells into bipotent mesenchymal stem cells. Stem Cells. 2006;24:1914–22.
- 39, , , , , , , , , , . Derivation of clinically compliant MSCs from CD105+, CD24– differentiated human ESCs. Stem Cells. 2007;25:425–36.
- 40. Bone remodeling, energy metabolism, and the molecular clock. Cell Metab. 2008;7:7–10.
- 41, , . Mechanisms of bone repair and regeneration. Trends Mol Med. 2009;15:417–29.
- 42, . Regulation of FoxO activity by CBP/p300-mediated acetylation. Trends Biochem Sci. 2005;30:81–6.
- 43, , , , , , , , , , , , , , , , , , , . Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLoS One. 2007;2:e1058.
- 44, , , , . Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting β-catenin from T cell factor- to forkhead box O-mediated transcription. J Biol Chem. 2007;282:27298–305.
- 45, , , , . Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton. J Biol Chem. 2009;284:27438–48.
- 46, . Gone with the Wnts: β-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism. Mol Endocrinol. 2007;21:2605–14.
- 47, , , , , , , , , , . FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab. 2010;11:136–46.