Results of this study were presented in preliminary form at the 29th Annual Meeting of American Society of Bone and Mineral Research and at the 35th European Symposium on Calcified Tissues.
Clinical Trials
You have full text access to this OnlineOpen article
Effect of vitamin D3 and calcium on fracture risk in 65- to 71-year-old women: A population-based 3-year randomized, controlled trial—the OSTPRE-FPS†
Article first published online: 29 JAN 2010
DOI: 10.1002/jbmr.48
Copyright © 2010 American Society for Bone and Mineral Research
Additional Information
How to Cite
Salovaara, K., Tuppurainen, M., Kärkkäinen, M., Rikkonen, T., Sandini, L., Sirola, J., Honkanen, R., Alhava, E. and Kröger, H. (2010), Effect of vitamin D3 and calcium on fracture risk in 65- to 71-year-old women: A population-based 3-year randomized, controlled trial—the OSTPRE-FPS. J Bone Miner Res, 25: 1487–1495. doi: 10.1002/jbmr.48
- †
Publication History
- Issue published online: 30 JUN 2010
- Article first published online: 29 JAN 2010
- Manuscript Accepted: 19 JAN 2010
- Manuscript Revised: 26 NOV 2009
- Manuscript Received: 20 AUG 2009
References
- 1, , , . Treatment of vitamin D deficiency increases lower limb muscle strength in institutionalized older people independently of regular physical activity: a randomized double-blind controlled trial. Ann Nutr Metab. 2009; 54: 291–300.
- 2, , , et al. Is fall prevention by vitamin D mediated by a change in postural or dynamic balance? Osteoporos Int. 2006; 17: 656–663.
- 3, , , , , . Vitamin D and bone health in the elderly. Am J Clin Nutr. 1982; 36: 1014–1031.
- 4, , , et al. The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects. J Clin Endocrinol Metab. 1988; 67: 644–650.
- 5, , , . Suomalaisten D-vitamiinitilanteen kohentaminen – auringosta, ruoasta vai purkista? Suom Lääkäril. 2003; 58: 1055–1056.
- 6. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001; 22: 477–501.
- 7, , , , , , . Effect of Vitamin D on falls: a meta-analysis. JAMA. 2004; 291: 1999–2006.
- 8, , , , , . Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA. 2005; 293: 2257–2264.
- 9, , , , , . Need for additional calcium to reduce the risk of hip fracture with vitamin d supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab. 2007; 92: 1415–1423.
- 10, , , , . Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet. 2007; 370: 657–666.
- 11, , , , . Vitamin D deficiency and bone health in healthy adults in Finland: could this be a concern in other parts of Europe? J Bone Miner Res. 2001; 16: 2066–2073.Direct Link:
- 12, , , , . Vitamin D deficiency in homebound elderly persons. JAMA. 1995; 274: 1683–1686.
- 13, , , , . Vitamin D status of an outpatient clinic population. Calcif Tissue Int. 2001; 69: 263–267.
- 14, , , . Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women. BMJ. 1994; 308: 1081–1082.
- 15, , , , , , , . Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study. Osteoporos Int. 2002; 13: 257–264.
- 16, , , . Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997; 337: 670–676.
- 17, , . Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ. 2003; 326: 469.
- 18, , . Vitamin D and calcium supplementation prevents osteoporotic fractures in elderly community dwelling residents: a pragmatic population-based 3-year intervention study. J Bone Miner Res. 2004; 19: 370–378.Direct Link:
- 19, , , , , , , , . Annual injection of vitamin D and fractures of aged bones. Calcif Tissue Int. 1992; 51: 105–110.
- 20, , , , . Vitamin D supplementation and fracture incidence in elderly persons. A randomized, placebo-controlled clinical trial. Ann Intern Med. 1996; 124: 400–406.
- 21, , , , , . Can vitamin D supplementation reduce the risk of fracture in the elderly? A randomized controlled trial. J Bone Miner Res. 2002; 17: 709–715.Direct Link:
- 22, , , , , , , , , , , , , , . Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care. BMJ. 2005; 330: 1003.
- 23, , , , , , , , , , , , , . RECORD Trial Group. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet. 2005; 365: 1621–1628.
- 24, , , , , . Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res. 2000; 15: 1113–1118.Direct Link:
- 25, , , , , . Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int. 2009; 20: 315–322.
- 26, , , , , , , , , . Should older people in residential care receive vitamin D to prevent falls? Results of a randomized trial. J Am Geriatr Soc. 2005; 53: 1881–1888.Direct Link:
- 27, , , , , , , , . Preventing fractures among older people living in institutional care: a pragmatic randomised double blind placebo controlled trial of vitamin D supplementation. Osteoporos Int. 2007; 18: 811–818.
- 28, , , , . Osteoporosis risk factors, gynaecological history and fractures in perimenopausal women--the results of the baseline postal enquiry of the Kuopio Osteoporosis Risk Factor and Prevention Study. Maturitas. 1993; 17: 89–100.
- 29, , , , . FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int. 2008; 19: 385–397.
- 30, , , , , . The burden of osteoporotic fractures: a method for setting intervention thresholds. Osteoporos Int. 2001; 12: 417–427.
- 31. How to select the doses of vitamin D in the management of osteoporosis. Osteoporos Int. 2007; 18: 401–407.
- 32, , , , , , , , , , . Vitamin-D 800IU/Day+Calcium 1000mg Supplementation Decreases the Risk of Falling Among Postmenopausal Ambulatory Women – A Population-based, Randomized 3-Year Study (OSTPRE-FPS). J Bone Miner Res. 2007; 22(S1): S117.
- 33, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , . Women's Health Initiative Investigators. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 2006; 354: 669–683.
- 34, , , , , , , , . Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med. 2009; 169: 551–561.
- 35, , , , , . Effect of calcium supplementation on fracture risk: a double-blind randomized controlled trial. Am J Clin Nutr. 2008; 87: 1945–1951.
- 36, , , , . Validity of self-reports of fractures in perimenopausal women. Am J Epidemiol. 1999; 150: 511–516.

1523-4681/asset/olbannerleft.gif?v=1&s=d7e4c0e37904a489128d3a4e58ba94214db307a9)
1523-4681/asset/olbannerright.gif?v=1&s=854ee0e4d351ead9faaca8bfab3e50b1c7c9d03d)
1523-4681/asset/cover.gif?v=1&s=a8419ff5f302b0d9fefec557d81c0aa9776c60e3)