Perspective

You have free access to this content

Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research

  1. John P Bilezikian1,*,
  2. Aliya Khan2,
  3. John T Potts Jr3,
  4. Maria Luisa Brandi4,
  5. Bart L Clarke5,
  6. Dolores Shoback6,
  7. Harald Jüppner3,7,
  8. Pierre D'Amour8,
  9. John Fox9,
  10. Lars Rejnmark10,
  11. Leif Mosekilde10,
  12. Mishaela R Rubin1,
  13. David Dempster11,
  14. Rachel Gafni12,
  15. Michael T Collins12,
  16. Jim Sliney1,
  17. James Sanders13

Article first published online: 21 SEP 2011

DOI: 10.1002/jbmr.483

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 26, Issue 10, pages 2317–2337, October 2011

Additional Information

How to Cite

Bilezikian, J. P., Khan, A., Potts, J. T., Brandi, M. L., Clarke, B. L., Shoback, D., Jüppner, H., D'Amour, P., Fox, J., Rejnmark, L., Mosekilde, L., Rubin, M. R., Dempster, D., Gafni, R., Collins, M. T., Sliney, J. and Sanders, J. (2011), Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research. J Bone Miner Res, 26: 2317–2337. doi: 10.1002/jbmr.483

Author Information

  1. 1

    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA

  2. 2

    Divisions of Endocrinology and Geriatrics, McMaster University, Hamilton, Ontario, Canada

  3. 3

    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

  4. 4

    Unit of Bone and Mineral Metabolism, Department of Internal Medicine, University of Florence Medical School, Florence, Italy

  5. 5

    Department of Medicine, Mayo Clinic, Rochester, MN, USA

  6. 6

    San Francisco VA Medical Center Endocrine Research Unit, University of California San Francisco, San Francisco, CA, USA

  7. 7

    Pediatric Nephrology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

  8. 8

    Centre de recherché, Centre hospitalier de l'Université de Montréal (CHUM)–Hôpital Saint-Luc and Department of Medicine, Université de Montréal, Montreal, Quebec, Canada

  9. 9

    NPS Pharmaceuticals, Bedminster, NJ, USA

  10. 10

    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

  11. 11

    Regional Bone Center, Helen Hayes Hospital, West Haverstraw, NY, USA, and Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY, USA

  12. 12

    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA

  13. 13

    Hypoparathyroidism Association, Idaho Falls, ID, USA

*Department of Medicine, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.

Publication History

  1. Issue published online: 21 SEP 2011
  2. Article first published online: 21 SEP 2011
  3. Accepted manuscript online: 2 AUG 2011 11:35AM EST
  4. Manuscript Accepted: 7 JUL 2011
  5. Manuscript Revised: 5 JUL 2011
  6. Manuscript Received: 16 MAR 2011

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (1170K)

Keywords:

  • HYPOPARATHYROIDISM;
  • CALCIUM;
  • EPIDEMIOLOGY;
  • GENETICS;
  • PARATHYROID HORMONE;
  • HYPOCALCEMIA

Abstract

Recent advances in understanding the epidemiology, genetics, diagnosis, clinical presentations, skeletal involvement, and therapeutic approaches to hypoparathyroidism led to the First International Workshop on Hypoparathyroidism that was held in 2009. At this conference, a group of experts convened to discuss these issues with a view towards a future research agenda for this disease. This review, which focuses primarily on hypoparathyroidism in the adult, provides a comprehensive summary of the latest information on this disease. © 2011 American Society for Bone and Mineral Research

View Full Article (HTML) Get PDF (1170K)