Perspective
You have free access to this content
Forum on aging and skeletal health: Summary of the proceedings of an ASBMR workshop
Article first published online: 13 SEP 2011
DOI: 10.1002/jbmr.488
Copyright © 2011 American Society for Bone and Mineral Research
Additional Information
How to Cite
Khosla, S., Bellido, T. M., Drezner, M. K., Gordon, C. M., Harris, T. B., Kiel, D. P., Kream, B. E., LeBoff, M. S., Lian, J. B., Peterson, C. A., Rosen, C. J., Williams, J. P., Winer, K. K. and Sherman, S. S. (2011), Forum on aging and skeletal health: Summary of the proceedings of an ASBMR workshop. J Bone Miner Res, 26: 2565–2578. doi: 10.1002/jbmr.488
Publication History
- Issue published online: 20 OCT 2011
- Article first published online: 13 SEP 2011
- Manuscript Accepted: 14 JUL 2011
- Manuscript Received: 6 JUL 2011
References
- 1US Department of Health and Human Services. The frequency of bone disease. In: Bone health and osteoporosis: a report of the surgeon general. Rockville, MD: US Department of Health and Human Services, Office of the Surgeon General; 2004, pp 68–87.
- 2, , , , . The diagnosis of osteoporosis. J Bone Miner Res. 1994; 9: 1137–41.
- 3National Osteoporosis Foundation (NOF). America's bone health: the state of osteoporosis and low bone mass in our nation. Washington, DC: NOF; 2002.
- 4, , , , , . Incidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025. J Bone Miner Res. 2007; 22: 465–75.
- 5, , , . The development of metaphyseal cortex: implications for distal radius fractures during growth. J Bone Miner Res. 2001; 16: 1547–55.
- 6, , , , , , , . Relationship of sex hormones to bone geometric properties and mineral density in early pubertal girls. J Clin Endocrinol Metab. 2004; 89: 1698–703.
- 7, . Changes in bone density during childhood and adolescence: an approach based on bone's biologic organization. J Bone Miner Res. 2001; 16: 597–604.
- 8, . Winning the battle against childhood physical inactivity: the key to bone strength? J Bone Miner Res. 2008; 23: 980–5.
- 9, , , , , . Targeted excerside against osteoporosis: a systemic review and meta-analysis for optimising bone strength throughout life. BMC Med. 2010; 8: 47.
- 10, , , , , , , , , , , , , , , . International Society for Clinical Desitometry 2007 adult and pediatric official postions. Bone. 2008; 43: 1115–21.
- 11, , , , , , , , . Longitudinal assessment of bone density and structure in an insident cohort of children with Crohn's disease. Gastroenterology. 2009; 136: 123–30.
- 12, , , , , , , , , , , , , . Improvement in biomarkers of bone formation during infliximab therapy in pediatric Crohn's disease: results of the REACH study. Clin Gastroenterol Hepatol. 2008; 6: 1378–84.
- 13, , , , , , , , , , , . Height adjustment in assessing dual energy X-ray absorptiometry measurements of bone mass and density in children. J Clin Endocrinol Metab. 2010; 95: 1265–73.
- 14, , . Calcium and vitamin D: what is known about effect on growing bone. Pediatrics. 2007; 119 (Suppl 2): S141–4.
- 15, , , . The receptor-dependent actions of 1,25-dihyroxyvitamin D are required for normal growth plate maturation in Npt2a knockout mice. Endocrinology. 2010; 151: 4607–12.
- 16, , , , , , , . Bone marrow changes in adolescent girls with anorexia nervosa. J Bone Miner Res. 2010; 25: 298–304.
- 17, , , , , , , , , , , . Hutchinson-Gilford progeria is a sleletal dysplasia. J Bone Miner Res. 2011; 26: 1670–1679.
- 18, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Consortium GFfOG. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet. 2009; 41: 1199–206.
- 19, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , . A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quatitative traits. Nat Genet. 2009; 41: 527–34.
- 20, , , , , , , , , , , , , , , , , , , , , , , , , , , , , . An integration of genome-wide assosication study and gene expression profiling to prioritize the discover of novel susceptibility Loct for osteoporosis-related traits. PLoS Genet. 2010; 6: e1000977.
- 21, , , , , , . Basic epidemiology of fractures of the upper and lower limb among Americans over 65 years of age. Epidemiology. 1996; 7: 612–8.
- 22, , , , , . Hip fracture incidence among elderly Hispanics. Am J Public Health. 1998; 88: 1245–7.
- 23, , , , , . Hip fracture incidence among elderly Asian-American populations. Am J Epidemiol. 1997; 146: 502–9.
- 24, , , , , , , . Longitudinal study of changes in hip bone mineral density in Caucasian and African-American women. J Am Geriatr Soc. 2005; 53: 183–9.
- 25, , , , , , , . Body size accounts for most differences in bone density between Asian and Caucasian women. Calcif Tissue Int. 1996; 59: 339–43.
- 26, , , , , , , , , , . Bone mineral density changes during the menopause transition in a multiethnic cohort of women. J Clin Endocrinol Metab. 2008; 93: 861–68.
- 27, , , , , . Patterns of FGF-23, DMP1, and MEPE expression in patients with chronic kidney disease. Bone. 2009; 45: 1161–8.
- 28, , , , , , , , , . Early control of PTH and FGF23 in normophosphatemic CKD patients: a new target in CKD-MBD therapy? Clin J Am Soc Nephrol. 2010; 5: 286–91.
- 29, , , , , , , , , , , , , Observational WsHI. Cyctatin-C, renal function, and incidence of hip fracture in postmenopausal women. J Am Geriatr Soc. 2008; 56: 1434–41.
- 30, , , , , , , , , . Fall prevention with supplement and active forms of vitamine D: a meta-analysis of randomised controlled trials. BMJ. 2009; 339: b3692.
- 31, , , , , , . Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev. 2009; 2: CD007146.
- 32, , , , , , . Annual high-dose oral vitamine D and falls and fractures in older women: a randomized controlled trial. JAMA. 2010; 303: 1815–22.
- 33, , , , , , , , . Once-weekly dose of 8400 IU vitamin D(3) compared with placebo: effects on neuromuscular function and tolerability in older adults with vitamin D unsufficiency. Am J Clin Nutr. 2010; 91: 985–91.
- 34, . The epidemiology of falls and syncope. Clin Geriatr Med. 2002; 18: 141–58.
- 35, . An older adult falls reserach agenda from a public health perspective. Clin Geriatr Med. 2010; 26: 767–79.
- 36, , , , , . Primary care-relevant interventions to prevent falling in older adults: a systematic evidence review for the US Preventive Services Task Force. Ann Intern Med. 2010; 153: 815–25.
- 37, , , , , , , , , , , , , . Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009; 460: 392–5.
- 38. Bone “mass” and the “mechanostat”: A proposal. Anat Rec. 1987; Jan; 219: 9.
- 39, , , , , , , , . Effects of sex, race, and puberty on cortical bone and the functional muscle bone unite in children, adolescents, and young adults. J Clin Endocrinol Metab. 2010; 95: 1681–9.
- 40, , , , , . Bone structure and volumetric BMD in overweight children: a longitudinal study. J Bone Miner Res. 2008; 23: 1946–53.
- 41, , , , , , , , , , . Age- and sex-specific differences in the factor of risk for vertebral fracture: a population-based study using QCT. J Bone Miner Res. 2006; 21: 1475–82.
- 42, , , , , , . Age-dependence of femoral strength in white women and men. J Bone Miner Res. 2010; 25: 994–1001.
- 43, , , , , , , , . Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metab. 2007; 5: 464–75.
- 44. Osteocyte messages from a bony tomb. Cell Metab. 2007; 5: 410–1.
- 45. The amazing osteocyte. J Bone Miner Res. 2011; 26: 229–38.
- 46
- 47, , . Effects of exercise involving predominantly either joint-reaction or ground-reaction forces on bone mineral density in older women. J Bone Miner Res. 1997; 12: 1253–61.
- 48, . BMD decreases over the course of a year in competitive male cyclists. J Bone Miner Res. 2008; 23: 484–91.
- 49, , , , , . Acute calcium ingestion attenuates exercise-induced disruption of calcium homeostasis. Med Sci Sports Exerc. 2011; 43: 617–23.
- 50, . Puzzles, promises and a cure for ageing. Nature. 2008; 454: 1065–71.
- 51, , , . Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med. 2010; 16: 238–46.
- 52, . Four faces of cellular senescence. J Cell Biol. 2011; 192: 547–56.
- 53, , , , . Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum. 2010; 62: 791–801.
- 54, , , . Linkage of chondrocyte apoptosis and cartilabe degradation in human osteoarthritis. Arthritis Rheum. 1998; 41: 1632–8.
- 55, , , , , , , , , , , , . MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging. Aging Cell. 2011; 10: 493–505.
- 56, , , , , , , , , , , . Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu, Zn superoxide dismutase. Aging Cell. DOI: 10.1111/j.1474-9726.2011.00709.x.
- 57, , , . Reduced satellite cell numbers and mygenic capacity in aging can be alleviated by endurance excersise. Plos ONE. 2010; 5: e13307.
- 58, , , , , . Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005; 433: 760–4.
- 59, , , , . A population of myogenic stem cells that survives skeletal muscle aging. Stem Cells. 2007; 25: 885–94.
- 60, , , , , , . Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science. 2007; 317: 807–10.
- 61, , , . The depletion of skeletal muscle satellite cells with ate is concomitant with reduced capacity of single progenitors to produce reserve progeny. Dev Biol. 2010; 340: 330–43.
- 62, , , . Sex steroids and bone mass: a study of changes about the time of menopause. J Clin Invest. 1987; 80: 1261–9.
- 63, , , . Characterization of perimenopausal bone loss: a prospective study. J Bone Miner Res. 2000; 15: 1965–73.
- 64, , , , . The menopausal transition: a 9-year prospective population-based study. The Melbourne Women's Midlife Health Project. Climacteric. 2004; 7: 375–89.
- 65, , , , , , , , . Hormone predictors of bone mineral density changes during the menopausal transition. J Clin Endocrinal Metab. 2006; 91: 1261–7.
- 66, , , , . Bone loss and bone size after menopause. N Engl J Med. 2003; 349: 327–34.
- 67, , , , , , , , , , , . Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem. 2007; 282: 27285–97.
- 68, . Gone with the Wnts: β-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism. Mol Endocrinol. 2007; 21: 2605–14.
- 69, , , , . Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-γ expression, and diminished pro-osteogenic Wnt signaling in the skeleton. J Biol Chem. 2009; 284: 27438–48.
- 70, , , , , , , , , , . Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice. Aging Cell. 2010; 9: 147–61.
- 71, , , , , , . Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α. J Clin Invest. 2000; 106: 1229–37.
- 72, , , , , , . Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo. Proc Natl Acad Sci USA. 2001; 98: 13960–5.
- 73, , , , , , , , . Ovariectomy disregulates osteoblast and osteoclast formation through the T-cell receptor CD40 ligand. Proc Natl Acad Sci USA. 2011; 108: 768–73.
- 74, , , , , , , , , . Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation. Proc Natl Acad Sci USA. 2007; 104: 15087–92.
- 75, , , , . The molecular clock mediates leptin-regulated bone formation. Cell. 2005; 122: 803–15.
- 76, , , , , , , , , , , , , , . A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell. 2009; 138: 976–89.
- 77, , , , , , , , , , , , . Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature. 2005; 434: 514–20.
- 78, , , , , , , , , , , , . Peripheral cannabinoid receptor, CB2, regulates bone mass. Proc Natl Acad Sci USA. 2006; 103: 696–701.
- 79, , , , , , . Hypothalmamic Y2 receptors regulate bone formation. J Clin Invest. 2002; 109: 915–21.

1523-4681/asset/olbannerleft.gif?v=1&s=d7e4c0e37904a489128d3a4e58ba94214db307a9)
1523-4681/asset/olbannerright.gif?v=1&s=854ee0e4d351ead9faaca8bfab3e50b1c7c9d03d)
