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Individual trabeculae segmentation (ITS)–based morphological analysis of high-resolution peripheral quantitative computed tomography images detects abnormal trabecular plate and rod microarchitecture in premenopausal women with idiopathic osteoporosis

  1. X Sherry Liu1,2,
  2. Adi Cohen2,
  3. Elizabeth Shane2,
  4. Emily Stein2,
  5. Halley Rogers2,
  6. Shannon L Kokolus2,
  7. Perry T Yin1,
  8. Donald J McMahon2,
  9. Joan M Lappe3,
  10. Robert R Recker3,
  11. X Edward Guo1,*

Article first published online: 2 FEB 2010

DOI: 10.1002/jbmr.50

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 25, Issue 7, pages 1496–1505, July 2010

Additional Information

How to Cite

Liu, X. S., Cohen, A., Shane, E., Stein, E., Rogers, H., Kokolus, S. L., Yin, P. T., McMahon, D. J., Lappe, J. M., Recker, R. R. and Guo, X. E. (2010), Individual trabeculae segmentation (ITS)–based morphological analysis of high-resolution peripheral quantitative computed tomography images detects abnormal trabecular plate and rod microarchitecture in premenopausal women with idiopathic osteoporosis. J Bone Miner Res, 25: 1496–1505. doi: 10.1002/jbmr.50

Author Information

  1. 1

    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USA

  2. 2

    Division of Endocrinology, Department of Medicine, Columbia University, New York, NY, USA

  3. 3

    Department of Medicine, Osteoporosis Research Center, Creighton University, Omaha, NB, USA

*Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, Mail Code 8904, 1210 Amsterdam Avenue, New York, NY 10027, USA.

Publication History

  1. Issue published online: 30 JUN 2010
  2. Article first published online: 2 FEB 2010
  3. Manuscript Accepted: 19 JAN 2010
  4. Manuscript Revised: 26 AUG 2009
  5. Manuscript Received: 30 JUN 2009

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References

  • 1
    NIH Consensus Development Panel on Osteoporosis Prevention. Consensus Development Conference Report: Prophylaxis and treatment of osteoporosis. Osteoporosis Int. 1991; 1: 114–117.
  • 2
    Peris P, Guanabens N, Martinez de Osaba MJ, et al. Clinical characteristics and etiologic factors of premenopausal osteoporosis in a group of Spanish women. Semin Arthritis Rheum. 2002; 32: 64–70.
  • 3
    Moreira Kulak CA, Schussheim DH, McMahon DJ, et al. Osteoporosis and low bone mass in premenopausal and perimenopausal women. Endocr Pract. 2000; 6: 296–304.
  • 4
    Lewiecki EM. Low bone mineral density in premenopausal women. South Med J. 2004; 97: 544–550.
  • 5
    Khan A. Premenopausal women and low bone density. Can Fam Physician. 2006; 52: 743–747.
  • 6
    Gourlay ML, Brown SA. Clinical considerations in premenopausal osteoporosis. Arch Intern Med. 2004; 164: 603–614.
  • 7
    Gennari L, Bilezikian JP. Osteoporosis in men. Endocrinol Metab Clin North Am. 2007; 36: 399–419.
  • 8
    Ebeling PR. Osteoporosis in men. New insights into aetiology, pathogenesis, prevention and management. Drugs Aging. 1998; 13: 421–434.
  • 9
    Cohen A, Shane E. Premenopausal osteoporosis. In: RosenCJ, ed. Primer on the Metabolic Bone Diseases and Other Disorders of Bone and MIneral Metabolism 7th ed., Washington, D.C., USA: American Society for Bone and Mineral Research; 2008: 289–293.
  • 10
    Cohen A, Fleischer J, Freeby MJ, McMahon DJ, Irani D, Shane E. Clinical characteristics and medication use among premenopausal women with osteoporosis and low BMD: the experience of an osteoporosis referral center. J Womens Health (Larchmt). 2009; 18: 79–84.
  • 11
    Khosla S, Lufkin EG, Hodgson SF, Fitzpatrick LA, Melton LJ 3rd. Epidemiology and clinical features of osteoporosis in young individuals. Bone. 1994; 15: 551–555.
  • 12
    Peris P, Martinez-Ferrer A, Monegal A, et al. Aetiology and clinical characteristics of male osteoporosis. Have they changed in the last few years? Clin Exp Rheumatol. 2008; 26: 582–588.
  • 13
    Peris P, Guanabens N, Monegal A, et al. Aetiology and presenting symptoms in male osteoporosis. Br J Rheumatol. 1995; 34: 936–941.
  • 14
    Kelepouris N, Harper KD, Gannon F, Kaplan FS, Haddad JG. Severe osteoporosis in men. Ann Intern Med. 1995; 123: 452–460.
  • 15
    Miller PD. Clinical use of bone mass measurements in adults for the assessment and management of osteoporosis. In: FavusMJ, ed. Primer on the Metabolic Bone Disease and Disorders of Mineral Metabolism. 6th ed. Washington DC: American Society for Bone and Mineral Research; 2006: pp. 150–161.
  • 16
    Katzman DK, Bachrach LK, Carter DR, Marcus R. Clinical and anthropometric correlates of bone mineral acquisition in healthy adolescent girls. J Clin Endocrinol Metab. 1991; 73: 1332–1339.
  • 17
    Carter DR, Bouxsein ML, Marcus R. New approaches for interpreting projected bone densitometry data. J Bone Miner Res. 1992; 7: 137–145.
    Direct Link:
  • 18
    Heaney RP, Abrams S, Dawson-Hughes B, et al. Peak bone mass. Osteoporos Int. 2000; 11: 985–1009.
  • 19
    Boutroy S, Bouxsein ML, Munoz F, Delmas PD. In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab. 2005; 90: 6508–6515.
  • 20
    Sornay-Rendu E, Boutroy S, Munoz F, Delmas PD. Alterations of cortical and trabecular architecture are associated with fractures in postmenopausal women, partially independent of decreased BMD measured by DXA: the OFELY study. J Bone Miner Res. 2007; 22: 425–433.
    Direct Link:
  • 21
    Melton LJ 3rd, Riggs BL, Keaveny TM, et al. Structural determinants of vertebral fracture risk. J Bone Miner Res. 2007; 22: 1885–1892.
    Direct Link:
  • 22
    Boutroy S, van Rietbergen B, Sornay-Rendu E, Munoz F, Bouxsein ML, Delmas PD. Finite Element Analyses Based on In Vivo HR-pQCT Images of the Distal Radius is Associated with Wrist Fracture in Postmenopausal Women. J Bone Miner Res. 2008; 23: 392–399.
    Direct Link:
  • 23
    Khosla S, Riggs BL, Atkinson EJ, et al. Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment. J Bone Miner Res. 2006; 21: 124–131.
    Direct Link:
  • 24
    Vico L, Zouch M, Amirouche A, et al. High-resolution pQCT analysis at the distal radius and tibia discriminates patients with recent wrist and femoral neck fractures. J Bone Miner Res. 2008; 23: 1741–1750.
    Direct Link:
  • 25
    Cohen A, Liu XS, McMahon DJ, et al. Bone Microarchitecture and Stiffness in Premenopausal Women With Idiopathic Osteoporosis. J Clin Endocrinol Metab. 2009; 94: 4351–4360.
  • 26
    Liu XS, Bevill G, Keaveny TM, Sajda P, Guo XE. Micromechanical analyses of vertebral trabecular bone based on individual trabeculae segmentation of plates and rods. J Biomech. 2009; 42: 249–256.
  • 27
    Liu XS, Sajda P, Saha PK, et al. Complete volumetric decomposition of individual trabecular plates and rods and its morphological correlations with anisotropic elastic moduli in human trabecular bone. J Bone Miner Res. 2008; 23: 223–235.
    Direct Link:
  • 28
    Liu XS, Sajda P, Saha PK, Wehrli FW, Guo XE. Quantification of the roles of trabecular microarchitecture and trabecular type in determining the elastic modulus of human trabecular bone. J Bone Miner Res. 2006; 21: 1608–1617.
    Direct Link:
  • 29
    Wehrli FW, Gomberg BR, Saha PK, Song HK, Hwang SN, Snyder PJ. Digital topological analysis of in vivo magnetic resonance microimages of trabecular bone reveals structural implications of osteoporosis. J Bone Miner Res. 2001; 16: 1520–1531.
    Direct Link:
  • 30
    Ding M, Hvid I. Quantification of age-related changes in the structure model type and trabecular thickness of human tibial cancellous bone. Bone. 2000; 26: 291–295.
  • 31
    Hildebrand T, Ruegsegger P. Quantification of bone microarchitecture with the structure model index. Comput Methods Biomech Biomed Engin. 1997; 1: 15–23.
  • 32
    Laib A, Hauselmann HJ, Ruegsegger P. In vivo high resolution 3D-QCT of the human forearm. Technol Health Care. 1998; 6: 329–337.
  • 33
    Parfitt AM, Mathews CH, Villanueva AR, Kleerekoper M, Frame B, Rao DS. Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest. 1983; 72: 1396–1409.
  • 34
    Zhang XH, Liu XS, Vasilic B, et al. In vivo µMRI based finite element and morphological analyses of tibial trabecular bone in eugonadal and hypogonadal men before and after testosterone treatment. J Bone Miner Res. 2008; 23: 1426–1434.
    Direct Link:
  • 35
    Macneil JA, Boyd SK. Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys. 2007; 29: 1096–1105.
  • 36
    Saha PK, Chaudhuri BB, Majumder DD. A new shape preserving parallel thinning algorithm for 3D digital images. Pattern Recogn. 1997; 30: 1939–1955.
  • 37
    Saha PK, Chaudhuri BB. Detection of 3-D simple points for topology preserving. IEEE Trans Pattern Anal Mach Intell. 1994; 16: 1028–1032.
  • 38
    Saha PK, Chaudhuri BB, Chanda B, Dutta Majumder D. Topology preservation in 3D digital space. Pattern Recogn. 1994; 27: 295–300.
  • 39
    Saha PK, Chaudhuri BB. 3D digital topology under binary transformation with applications. Comput Vis Image Underst. 1996; 63: 418–429.
  • 40
    Hollister SJ, Brennan JM, Kikuchi N. A homogenization sampling procedure for calculating trabecular bone effective stiffness and tissue level stress. J Biomech. 1994; 27: 433–444.
  • 41
    Van Rietbergen B, Odgaard A, Kabel J, Huiskes R. Direct mechanics assessment of elastic symmetries and properties of trabecular bone architecture. J Biomech. 1996; 29: 1653–1657.
  • 42
    Press WH, Teukolsky SA, Vetterling WT, Flannery BP. Numerical Recipes in Fortran. 2nd ed. Cambridge: Cambridge Univ. Press; 1992.
  • 43
    Donovan MA, Dempster D, Zhou H, McMahon DJ, Fleischer J, Shane E. Low bone formation in premenopausal women with idiopathic osteoporosis. J Clin Endocrinol Metab. 2005; 90: 3331–3336.
  • 44
    Liu XS, Zhang H, Sekhon KK, et al. High-resolution peripheral quantitative computed tomography can assess microstructural and mechanical properties of human distal tibial bone. J Bone Miner Res. 2010; 25: 746–756.
  • 45
    Liu XS, Sekhon KK, Zhang XH, Shane E, Bilezikian JP, Guo XE. Individual trabeculae segmentation based morphological analyses of registered HR-pQCT and µCT Images of human tibial bone. Trans Orthop Res Soc. 2009; 34: 2142.
  • 46
    Magland JF, Wehrli FW. Trabecular bone structure analysis in the limited spatial resolution regime of in vivo MRI. Acad Radiol. 2008; 15: 1482–1493.
  • 47
    Burghardt AJ, Kazakia GJ, Majumdar S. A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone. Ann Biomed Eng. 2007; 35: 1678–1686.
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