Article

Age and bone mass in premenopausal women

  1. Daniel I. Rosenthal M.D.1,*,
  2. William Mayo-Smith1,
  3. Curtis W. Hayes1,†,
  4. Jasvir S. Khurana1,
  5. Beverly M.K. Biller2,
  6. Robert M. Neer2,
  7. Anne Klibanski2

Article first published online: 3 DEC 2009

DOI: 10.1002/jbmr.5650040412

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 4, Issue 4, pages 533–538, August 1989

Additional Information

How to Cite

Rosenthal, D. I., Mayo-Smith, W., Hayes, C. W., Khurana, J. S., Biller, B. M.K., Neer, R. M. and Klibanski, A. (1989), Age and bone mass in premenopausal women. J Bone Miner Res, 4: 533–538. doi: 10.1002/jbmr.5650040412

Author Information

  1. 1

    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA

  2. 2

    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA

  1. †

    Department of Radiology, Medical College of Virginia, Richmond, VA

*Department of Radiology Massachusetts General Hospital Boston, MA 02114

Publication History

  1. Issue published online: 3 DEC 2009
  2. Article first published online: 3 DEC 2009
  3. Manuscript Accepted: 6 JAN 1989
  4. Manuscript Revised: 4 JAN 1989
  5. Manuscript Received: 20 JUN 1988

Funded by

  • National Institutes of Health. Grant Numbers: HD 21204, RR 01066

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Abstract

It is important to determine the bone mass in normal premenopausal women because increasing numbers of conditions have been identified that result in premenopausal osteoporosis. The relationship between age and bone density was evaluated in 57 carefully characterized normal, premenopausal women using both single energy quantitative computed tomography (SEQCT) and dual energy (DEQCT). The mean bone density measurements were 172 mg/ml K2HPO4 SEQCT and 185 DEQCT. Bone density showed no statistically significant decline between age 18 and age 44. Single- and dual-energy data were highly correlated with each other (r = 0.89), and dual energy appeared to confer no advantage. There was an inverse relation between density and age of menarche. Bone density did not correlate with ideal body weight, percentage fat, or subcutaneous fat area.

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