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Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: The EPIDOS study

  1. Cédric Annweiler1,*,
  2. Anne-Marie Schott2,
  3. Manuel Montero-Odasso3,
  4. Gilles Berrut4,
  5. Bruno Fantino1,5,
  6. François R Herrmann6,
  7. Olivier Beauchet1

Article first published online: 4 MAR 2010

DOI: 10.1002/jbmr.80

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 25, Issue 8, pages 1858–1866, August 2010

Additional Information

How to Cite

Annweiler, C., Schott, A.-M., Montero-Odasso, M., Berrut, G., Fantino, B., Herrmann, F. R. and Beauchet, O. (2010), Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: The EPIDOS study. J Bone Miner Res, 25: 1858–1866. doi: 10.1002/jbmr.80

Author Information

  1. 1

    Department of Internal Medicine and Geriatrics, Angers University Hospital; UPRES EA2646, University of Angers, UNAM, Angers, France

  2. 2

    Department IMER, Lyon University Hospital; EA4129, RECIF, University of Lyon; INSERM 4831, Lyon, France

  3. 3

    Department of Medicine, Division of Geriatric Medicine, University of Western Ontario, London, Ontario, Canada

  4. 4

    Department of Geriatrics, Nantes University Hospital and University of Nantes, Nantes, France

  5. 5

    Medical Health Center, CNAMTS, Lyon, France

  6. 6

    Department of Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland

*Department of Internal Medicine and Geriatrics, Angers University Hospital, 49933 Angers Cedex 9, France.

Publication History

  1. Issue published online: 30 JUL 2010
  2. Article first published online: 4 MAR 2010
  3. Manuscript Accepted: 25 FEB 2010
  4. Manuscript Revised: 5 DEC 2009
  5. Manuscript Received: 18 APR 2009

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Keywords:

  • vitamin D;
  • walking speed;
  • fast pace;
  • motor coordination;
  • aging

Abstract

The purpose of this study was to determine whether there was an association between serum 25-hydroxyvitamin D [25(OH)D] concentration and walking speed measured at usual and fast pace among older women. Usual- and fast-pace walking speeds and 25(OH)D concentrations were assessed in 739 randomized older women (mean age 80.2 ± 3.5 years) from the EPIDOS study. The following 25(OH)D thresholds were used: 10, 20, and 30 ng/mL. Walking speed was dichotomized on being in the worst quintile or not. Age, body mass index, number of chronic diseases, physical activity, quadriceps strength, cognition, use of psychoactive drugs, and serum parathyroid hormone were used as potential confounders. The results show that 90% of subjects had 25(OH)D insufficiency. Only fast-pace walking speed was significantly different between groups (p = .021) and decreased from normal serum 25(OH)D concentrations to severe insufficiency (trend p = .007). Serum 25(OH)D concentration was associated with walking speed at both usual and fast pace in the unadjusted linear regression (β = 0.16, p = .027 and β = 0.23, p = .009, respectively). This association remained significant only for fast-pace walking after adjustment (adjusted β = 0.18, p = .033) and was strengthened from a lower 25(OH)D value compared with usual pace [25(OH)D = 27.15 ng/mL for fast pace and 38.65 ng/mL for usual pace). Lastly, logistic regression showed a stronger association of serum 25(OH)D insufficiency with fast-pace walking speed whatever the 25(OH)D thresholds used [30 to 20 ng/mL: adjusted odds ratio (adjOR) = 6.01, p = .003; 20 to 10 ng/mL: adjOR = 4.10, p = .014; <10 ng/mL: adjOR = 6.95, p = .001) compared with usual pace (30 to 20 ng/mL: adjOR = 3.79, p = .022; 20 to 10 ng/mL: adjOR = 3.76, p = .016; <10 ng/mL: adjOR = 5.44, p = .003). The findings show a stronger positive association between 25(OH)D concentrations and fast-pace walking speed that is a more sensitive marker of neuromuscular functioning compared with usual-pace walking. © 2010 American Society for Bone and Mineral Research

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