Small noncoding RNAs: Biogenesis, function, and emerging significance in toxicology

Authors

  • Supratim Choudhuri

    Corresponding author
    1. Center for Food Safety and Applied Nutrition, Division of Biotechnology and GRAS Notice Review, U.S. Food and Drug Administration, College Park, MD 20740, USA
    • Center for Food Safety and Applied Nutrition, Division of Biotechnology and GRAS Notice Review, U.S. Food and Drug Administration, College Park, MD 20740, USA
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  • Declaration of interest: The author reports no conflicts of interest. The author alone is responsible for the content and writing of the article.

    The opinions expressed in this article are the author's personal opinions and do not reflect those of FDA, DHHS, or the Federal Government.

Abstract

In recent years, the discovery of small ncRNAs (noncoding RNAs) has unveiled a slew of powerful riboregulators of gene expression. So far, many different types of small ncRNAs have been described. Of these, miRNAs (microRNAs), siRNAs (small interfering RNAs), and piRNAs (Piwi-interacting RNAs) have been studied in more detail. A significant fraction of genes in most organisms and tissues is targets of these small ncRNAs. Because these tiny RNAs are turning out to be important regulators of gene and genome expression, their aberrant expression profiles are expected to be associated with cellular dysfunction and disease. In fact, an ever-increasing number of studies have implicated miRNAs and siRNAs in human health and disease ranging from metabolic disorders to diseases of various organ systems as well as various forms of cancer. Nevertheless, despite the flurry of research on these small ncRNAs, many aspects of their biology still remain to be understood. The following discussion focuses on some aspects of the biogenesis and function of small ncRNAs with major emphasis on miRNAs since these are the most widespread endogenous small ncRNAs that have been called “micromanagers” of gene expression. Their emerging significance in toxicology is also discussed. © 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 24:195–216, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20325

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