Biogenesis of MiRNA-195 and its role in biogenesis, the cell cycle, and apoptosis

Authors

  • Jun-Feng He,

    1. Department of Cardiology, Shenzhen Longgang District People's Hospital, Guang Dong Medicine College, Shenzhen, 518172, People's Republic of China
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  • Yu-Mei Luo,

    1. Department of Cardiology, Shenzhen Longgang District People's Hospital, Guang Dong Medicine College, Shenzhen, 518172, People's Republic of China
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  • Xin-Hong Wan,

    Corresponding author
    1. Department of Cardiology, Shenzhen Longgang District People's Hospital, Guang Dong Medicine College, Shenzhen, 518172, People's Republic of China
    • Department of Cardiology, Shenzhen Longgang District People's Hospital, Guang Dong Medicine College, Shenzhen, 518172, People's Republic of China
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  • Deqian Jiang

    1. Department of Cardiology, the Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People's Republic of China
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Abstract

microRNA-195(miR-195) is an important member of the micro-15/16/195/424/497 family, and which is activated in multiple diseases, such as cancers, heart failure, and schizophrenia. Mir-195 regulates a plethora of target proteins, which are involved in the cell cycle, apoptosis, proliferation. WEE1, CDK6, and Bcl-2 are confirmed target genes of miR-195 that are involved in miR-195-mediated cell-cycle and apoptosis effects. However, the mechanism of miR-195 action is not completely understood. This review summarizes recent the research progress regarding the roles of miR-195 in the cell cycle and in apoptosis. © 2011 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25:404–408 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.20396

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