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Endocrine and metabolic regulation of renal drug transporters

Authors

  • Lindsay L. Yacovino,

    1. Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, NJ 08854-8020, USA
    2. Joint Graduate Program in Toxicology, Rutgers University/UMDNJ, Piscataway, NJ 08854, USA
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  • Lauren M. Aleksunes

    Corresponding author
    1. Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, NJ 08854-8020, USA
    2. Environmental and Occupational Health Sciences Institute, A Joint Institute of Robert Wood Johnson Medical School and Rutgers University, Piscataway, NJ 08854, USA
    • Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, NJ 08854-8020, USA
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Abstract

Renal xenobiotic transporters are important determinants of urinary secretion and reabsorption of chemicals. In addition to glomerular filtration, these processes are key to the overall renal clearance of a diverse array of drugs and toxins. Alterations in kidney transporter levels and function can influence the efficacy and toxicity of chemicals. Studies in experimental animals have revealed distinct patterns of renal transporter expression in response to sex hormones, pregnancy, and growth hormone. Likewise, a number of disease states including diabetes, obesity, and cholestasis alter the expression of kidney transporters. The goal of this review is to provide an overview of the major xenobiotic transporters expressed in the kidneys and an understanding of metabolic conditions and hormonal factors that regulate their expression and function. © 2012 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:407–421, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21435

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