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Research Article

Accumulation and Endocrine Disrupting Effects of the Flame Retardant Mixture Firemaster® 550 in Rats: An Exploratory Assessment

  1. Heather B. Patisaul1,2,*,
  2. Simon C. Roberts3,
  3. Natalie Mabrey1,
  4. Katherine A. McCaffrey1,
  5. Robin B. Gear4,
  6. Joe Braun5,
  7. Scott M. Belcher4,
  8. Heather M. Stapleton3

Article first published online: 8 NOV 2012

DOI: 10.1002/jbt.21439

Issue

Journal of Biochemical and Molecular Toxicology

Journal of Biochemical and Molecular Toxicology

Special Issue: Special Issue 2: National Institute of Environmental Health Sciences Outstanding New Environmental Scientist Program

Volume 27, Issue 2, pages 124–136, February 2013

Additional Information

How to Cite

Patisaul, H. B., Roberts, S. C., Mabrey, N., McCaffrey, K. A., Gear, R. B., Braun, J., Belcher, S. M. and Stapleton, H. M. (2013), Accumulation and Endocrine Disrupting Effects of the Flame Retardant Mixture Firemaster® 550 in Rats: An Exploratory Assessment. J. Biochem. Mol. Toxicol., 27: 124–136. doi: 10.1002/jbt.21439

Author Information

  1. 1

    Department of Biology, North Carolina State University, Raleigh, NC, USA

  2. 2

    Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC, USA

  3. 3

    Nicholas School of the Environment, Duke University, Durham, NC, USA

  4. 4

    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH, USA

  5. 5

    Department of Epidemiology, Brown University, Providence, RI, USA

*Correspondence to: Heather B Patisaul.

Publication History

  1. Issue published online: 18 FEB 2013
  2. Article first published online: 8 NOV 2012
  3. Manuscript Accepted: 6 SEP 2012
  4. Manuscript Revised: 3 AUG 2012
  5. Manuscript Received: 22 JUL 2012

Funded by

  • HMS. Grant Number: R01 ES016099
  • HBP. Grant Number: R01 ES016001
  • SMB. Grant Numbers: R01 ES015145, RC2 ES018765

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Keywords:

  • Anxiety;
  • Cardiac Hypertrophy;
  • Endocrine Disruptor;
  • Flame Retardants;
  • Metabolic Syndrome;
  • Metabolism;
  • Obesity;
  • Obesogen;
  • Polybrominated Diphenyl Ethers;
  • Rodents

ABSTRACT

Firemaster® 550 (FM 550), a fire-retardant mixture used in foam-based products, was recently identified as a common contaminant in household dust. The chemical structures of its principle components suggest they have endocrine disrupting activity, but nothing is known about their physiological effects at environmentally relevant exposure levels. The goal of this exploratory study was to evaluate accumulation, metabolism and endocrine disrupting effects of FM 550 in rats exposed to 100 or 1000 µg/day across gestation and lactation. FM 550 components accumulated in tissues of exposed dams and offspring and induced phenotypic hallmarks associated with metabolic syndrome in the offspring. Effects included increased serum thyroxine levels and reduced hepatic carboxylesterease activity in dams, and advanced female puberty, weight gain, male cardiac hypertrophy, and altered exploratory behaviors in offspring. Results of this study are the first to implicate FM 550 as an endocrine disruptor and an obesogen at environmentally relevant levels. #x000A9; 2012 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:124-136, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21439

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