Contract Grant Sponsor: NIH.
Toxicity of Engineered Nanomaterials: A Physicochemical Perspective
Article first published online: 5 NOV 2012
© 2012 Wiley Periodicals, Inc.
Journal of Biochemical and Molecular Toxicology
Special Issue: Special Issue 1: National Institute of Environmental Health Sciences Outstanding New Environmental Scientist Program
Volume 27, Issue 1, pages 50–55, January 2013
How to Cite
Podila, R. and Brown, J. M. (2013), Toxicity of Engineered Nanomaterials: A Physicochemical Perspective. J. Biochem. Mol. Toxicol., 27: 50–55. doi: 10.1002/jbt.21442
Contract Grant Number: RO1 ES019311 (J. Brown).
- Issue published online: 17 JAN 2013
- Article first published online: 5 NOV 2012
- Manuscript Accepted: 8 SEP 2012
- Manuscript Revised: 14 AUG 2012
- Manuscript Received: 6 JUL 2012
- NIH. Grant Number: RO1 ES019311
- Protein Corona;
The global market for nanomaterial-based products is forecasted to reach 100 billion dollars per annum for 2011–2015. Extensive manufacturing and the use of engineered nanomaterials have raised concerns regarding their impact on biological response in living organisms and the environment at large. The fundamental properties of nanomaterials exhibit a complex dependence upon several factors such as their morphology, size, defects, and chemical stability. Therefore, it is exceedingly difficult to correlate their biological response with their intricate physicochemical properties. For example, varying toxic response may ensue due to different methods of nanomaterial preparation, dissimilar impurities, and defects. In this review, we surveyed the existing literature on the dependence of cytotoxicity on physicochemical properties. We found that ENM size, shape, defect density, physicochemical stability, and surface modification to be the main causes that elicit altered physiological response or cytotoxicity. © 2012 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:50-55, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21442