Carbamate Protection of AChE Against Inhibition by Agricultural Chemicals


  • This work was presented by Francisca Rusli and Michelle Ka Yan Tam at the 23rd Annual U.C. Davis Undergraduate Research, Scholarship & Creative Activities Conferences.

  • Contract Grant Sponsor: U.S. Department of Agriculture Western Regional Project W-2045.

    Contract Grant Number: 7504-RR.

  • Contract Grant Sponsor: University of California Department of Animal Science.

Correspondence to: Barry Wilson.


The carbamate pyridostigmine bromide has been used as a pretreatment to protect individuals from the nerve agent soman. Previous research showed that pyridostigmine significantly protected human muscle acetylcholinesterase in vitro from soman and bovine red blood cell acetylcholinesterase from some organophosphorous pesticides. Research presented here demonstrates that pretreatment with other carbamates also protects acetylcholinesterase from inhibition by the pesticides chlorpyrifos-oxon and diazinon-oxon, but not from malaoxon. © 2012 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:506-509, 2012; View this article online at DOI 10.1002/jbt.21456