Contract Grant Sponsor: National Institute of Environmental Health Sciences.
Arsenic and the Epigenome: Interindividual Differences in Arsenic Metabolism Related to Distinct Patterns of DNA Methylation
Article first published online: 11 JAN 2013
© 2013 Wiley Periodicals, Inc.
Journal of Biochemical and Molecular Toxicology
Special Issue: Special Issue 2: National Institute of Environmental Health Sciences Outstanding New Environmental Scientist Program
Volume 27, Issue 2, pages 106–115, February 2013
How to Cite
Bailey, K. A., Wu, M. C., Ward, W. O., Smeester, L., Rager, J. E., García-Vargas, G., Del Razo, L.-M., Drobná, Z., Stýblo, M. and Fry, R. C. (2013), Arsenic and the Epigenome: Interindividual Differences in Arsenic Metabolism Related to Distinct Patterns of DNA Methylation. J. Biochem. Mol. Toxicol., 27: 106–115. doi: 10.1002/jbt.21462
Contract Grant Numbers: P30ES010126, ES019315, ES015326, DK056350, and T32 ES007018.
- Issue published online: 18 FEB 2013
- Article first published online: 11 JAN 2013
- Manuscript Accepted: 24 OCT 2012
- Manuscript Revised: 9 OCT 2012
- Manuscript Received: 15 AUG 2012
- National Institute of Environmental Health Sciences. Grant Numbers: P30ES010126, ES019315, ES015326, DK056350, T32 ES007018
- DNA Methylation;
- Arsenic biotransformation
Biotransformation of inorganic arsenic (iAs) is one of the factors that determines the character and magnitude of the diverse detrimental health effects associated with chronic iAs exposure, but it is unknown how iAs biotransformation may impact the epigenome. Here, we integrated analyses of genome-wide, gene-specific promoter DNA methylation levels of peripheral blood leukocytes with urinary arsenical concentrations of subjects from a region of Mexico with high levels of iAs in drinking water. These analyses revealed dramatic differences in DNA methylation profiles associated with concentrations of specific urinary metabolites of arsenic (As). The majority of individuals in this study had positive indicators of As-related disease, namely pre-diabetes mellitus or diabetes mellitus (DM). Methylation patterns of genes with known associations with DM were associated with urinary concentrations of specific iAs metabolites. Future studies will determine whether these DNA methylation profiles provide mechanistic insight into the development of iAs-associated disease, predict disease risk, and/or serve as biomarkers of iAs exposure in humans. © 2012 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:106-115, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21462