Jordy Saravia and Greg I. Lee contributed equally.
Particulate Matter Containing Environmentally Persistent Free Radicals and Adverse Infant Respiratory Health Effects: A Review
Article first published online: 20 DEC 2012
© 2012 Wiley Periodicals, Inc.
Journal of Biochemical and Molecular Toxicology
Special Issue: Special Issue 1: National Institute of Environmental Health Sciences Outstanding New Environmental Scientist Program
Volume 27, Issue 1, pages 56–68, January 2013
How to Cite
Saravia, J., Lee, G. I., Lomnicki, S., Dellinger, B. and Cormier, S. A. (2013), Particulate Matter Containing Environmentally Persistent Free Radicals and Adverse Infant Respiratory Health Effects: A Review. J. Biochem. Mol. Toxicol., 27: 56–68. doi: 10.1002/jbt.21465
Contract Grant Sponsor: NIEHS. Contract Grant Numbers: R01ES015050 (to SAC), P42ES013648 (to BD and SAC).
Contract Grant Sponsor: Louisiana Board of Regents. Contract Grant Number: LEQSF (2009-14)-GF-08 (to JS).
Contract Grant Sponsor: NIAAA. Contract Grant Number: AA007577 (to GL).
The contents of this manuscript are solely the responsibility of the authors and do not necessarily represent the official views of NIH or the State of Louisiana.
- Issue published online: 17 JAN 2013
- Article first published online: 20 DEC 2012
- Manuscript Accepted: 3 NOV 2012
- Manuscript Revised: 25 OCT 2012
- Manuscript Received: 14 OCT 2012
- NIEHS. Grant Numbers: R01ES015050, P42ES013648
- Louisiana Board of Regents. Grant Number: 2009-14
- NIAAA. Grant Number: AA007577
- Particulate Matter;
- Environmentally Persistent Free Radicals;
- Respiratory Health;
The health impacts of airborne particulate matter (PM) are of global concern, and the direct implications to the development/exacerbation of lung disease are immediately obvious. Most studies to date have sought to understand mechanisms associated with PM exposure in adults/adult animal models; however, infants are also at significant risk for exposure. Infants are affected differently than adults due to drastic immaturities, both physiologically and immunologically, and it is becoming apparent that they represent a critically understudied population. Highlighting our work funded by the ONES award, in this review we argue the understated importance of utilizing infant models to truly understand the etiology of PM-induced predisposition to severe, persistent lung disease. We also touch upon various mechanisms of PM-mediated respiratory damage, with a focus on the emerging importance of environmentally persistent free radicals (EPFRs) ubiquitously present in combustion-derived PM. In conclusion, we briefly comment on strengths/challenges facing current PM research, while giving perspective on how we may address these challenges in the future. © 2012 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:56-68, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21465