Synthesis and Crystal Structure of Binuclear Copper(II) Complex Bridged by N-(2-Hydroxyphenyl)-N′-[3-(diethylamino)propyl]oxamide: In Vitro Anticancer Activity and Reactivity Toward DNA and Protein

Authors


  • Contract Grant Sponsor: National Natural Science Foundation of China.

  • Contract Grant Number: 21071133, 51273184, and 81202399.

  • Contract Grant Sponsor: Program for Science and Technology of Shandong Province.

  • Contract Grant Number: 2011GHY11521.

  • Contract Grant Sponsor: Natural Science Foundation of Qingdao City.

  • Contract Grant Number: 11-2-4-1-(9)gch, 12-1-3-52-(1)-nsh, and 12-1-4-16-(7)-jch.

Correspondence to: Yan-Tuan Li, and Cui-Wei Yan.

ABSTRACT

A new oxamido-bridged bicopper(II) complex, [Cu2(pdpox)(bpy)(CH3OH)](ClO4), where H3pdpox and bpy stand for N-(2-hydroxyphenyl)-N′-[3-(diethylamino)propyl]oxamide and 2,2′-bipyridine, respectively, has been synthesized and characterized by elemental analyses, molar conductivity measurements, infrared and electronic spectra studies, and X-ray single crystal diffraction. In the crystal structure, the pdpox3− ligand bridges two copper(II) ions as cisoid conformation. The inner copper(II) ion has a {N3O} square-planar coordination geometry, while the exo- one is in a {N2O3} square-pyramidal environment. There are two sets of interpenetrating two-dimensional hydrogen bonding networks parallel to the planes (2 1 0) and (math formula), respectively, to form a three-dimensional supramolecular structure. The bicopper(II) complex exhibits cytotoxic activity against the SMMC7721 and A549 cell lines. The reactivity toward herring sperm DNA and bovine serum albumin revealed that the bicopper(II) complex can interact with the DNA by intercalation mode, and the complex binds to protein BSA responsible for quenching of tryptophan fluorescence by static quenching mechanism. © 2013 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:412-424, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21504

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