Synthesis, Chemical Characterization, DNA Binding, Antioxidant, Antibacterial, and Antifungal Activities of Ferrocence Incorporated Selenoureas
Article first published online: 14 NOV 2013
© 2013 Wiley Periodicals, Inc.
Journal of Biochemical and Molecular Toxicology
Volume 28, Issue 2, pages 60–68, February 2014
How to Cite
Hussain, R. A., Badshah, A., Tahir, M. N., Hassan, T.-u.-. and Bano, A. (2014), Synthesis, Chemical Characterization, DNA Binding, Antioxidant, Antibacterial, and Antifungal Activities of Ferrocence Incorporated Selenoureas. J. Biochem. Mol. Toxicol., 28: 60–68. doi: 10.1002/jbt.21536
- Issue published online: 4 FEB 2014
- Article first published online: 14 NOV 2013
- Manuscript Accepted: 16 OCT 2013
- Manuscript Revised: 9 OCT 2013
- Manuscript Received: 3 AUG 2013
- DNA Binding Constant;
- Diffusion Coefficients;
- Binding Site Size;
Ferrocene-incorporated selenoureas 1-(4-methoxybenzoyl)-3-(4-ferrocenylphenyl)selenourea (P4Me), 1-(3-methoxybenzoyl)-3-(4-ferrocenylphenyl)selenourea (P3Me), and 1-(2-methoxybenzoyl)-3-(4-ferrocenylphenyl)selenourea (P2Me) were synthesized and characterized by nuclear magnetic resonance, Fourier transform infrared spectroscopy, atomic absorption spectroscopy, CHNS, and single-crystal X-ray diffraction. DNA interaction of the compounds was investigated with cyclic voltammetry, UV–visible spectroscopy, and viscometry, which is a prerequisite for anticancer agents. Drug-DNA binding constant was found to vary in the sequence: KP4Me (4.9000 × 104 M−1) > KP2Me (2.318 × 104 M−1) > KP3Me (1.296 × 104 M−1). Antioxidant (1,1-diphenyl-2-picrylhydrazyl), antifungal (against Faussarium solani and Helmentosporium sativum), and antibacterial (against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis) activities have also been reported in addition.