Contract Grant Sponsor: CNPq.
Preventive Effect of CuCl2 on Behavioral Alterations and Mercury Accumulation in Central Nervous System Induced by HgCl2 in Newborn Rats
Article first published online: 3 MAY 2014
© 2014 Wiley Periodicals, Inc.
Journal of Biochemical and Molecular Toxicology
Volume 28, Issue 7, pages 328–335, July 2014
How to Cite
Moraes-Silva, L., Siqueira, L. F., Oliveira, V. A., Oliveira, C. S., Ineu, R. P., Pedroso, T. F., Fonseca, M. M. and Pereira, M. E. (2014), Preventive Effect of CuCl2 on Behavioral Alterations and Mercury Accumulation in Central Nervous System Induced by HgCl2 in Newborn Rats. J. Biochem. Mol. Toxicol., 28: 328–335. doi: 10.1002/jbt.21569
Contract Grant Sponsor: CAPES.
Contract Grant Sponsor: FAPERGS.
- Issue published online: 17 JUL 2014
- Article first published online: 3 MAY 2014
- Manuscript Accepted: 7 APR 2014
- Manuscript Revised: 31 MAR 2014
- Manuscript Received: 16 DEC 2013
- Essential Metal;
- Newborn Rats;
- Motor Activity;
This study investigated the benefits of Cu preexposition on Hg effects on behavioral tests, acetylcholinesterase (AChE) activity and Hg, and essential metal contents in the cerebrum and cerebellum of neonate rats. Wistar rats received (subcutaneous) saline or CuCl2·2H2O (6.9 mg/kg/day) when they were 3 to 7 days old and saline or HgCl2 (5.0 mg/kg/day) when they were 8 to 12 days old. Mercury exposure reduced the performance of rats in the negative geotaxis (3–13 days) and beaker test (17–20 days), inhibited cerebellum AChE activity (13 days), increased cerebrum and cerebellum Hg (13 days), cerebrum Cu (13 days), and cerebrum and cerebellum Zn levels (33 days). The performance of rats in the tail immersion and rotarod tests as well as Fe and Mg levels were not altered by treatments. Copper prevented all alterations induced by mercury. These results are important to open a new perspective of prevention and/or therapy for mercury exposure.