Plasmapheresis for hemolytic crisis and impending acute liver failure in Wilson disease

Authors

  • Samuel Asfaha,

    1. Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
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  • Mohammed Almansori,

    1. Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
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  • Uwais Qarni,

    Corresponding author
    1. Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    2. Division of Nephrology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    • 107 F Clinical Sciences Building, University of Alberta, 8440-112 Street, Edmonton, AB T6G 2G3, Canada
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  • Klaus S. Gutfreund

    1. Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    2. Liver Unit, Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
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Abstract

Wilsonian crisis is fatal unless copper removal is initiated early and liver transplantation is performed for patients that fulfill criteria for a poor outcome. We report a patient presenting with severe hemolysis and impending acute liver failure that made a rapid recovery with prompt initiation of plasmapheresis and chelation therapy. Rapid copper removal by plasmapheresis alleviated hemolysis and liver injury. A review of the literature was performed examining the use of plasmapheresis and albumin dialysis with continuous veno-venous hemodialysis or molecular adsorbents and recirculating system. J. Clin. Apheresis, 2007. © 2007 Wiley-Liss, Inc.

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