Treatment of severe amitriptyline intoxication with plasmapheresis
Article first published online: 12 JAN 2009
Copyright © 2009 Wiley-Liss, Inc.
Journal of Clinical Apheresis
Volume 24, Issue 1, pages 21–24, 2009
How to Cite
Kolsal, E., Tekin, I. Ö., Piskin, E., Aydemir, C., Akyüz, M., Çabuk, H., Eldes, N. and Numanoglu, V. (2009), Treatment of severe amitriptyline intoxication with plasmapheresis. J. Clin. Apheresis, 24: 21–24. doi: 10.1002/jca.20185
- Issue published online: 2 FEB 2009
- Article first published online: 12 JAN 2009
- Manuscript Accepted: 21 NOV 2008
- Manuscript Received: 7 APR 2008
Tricyclic antidepressant poisoning is one of the most common causes of serious intoxication. Here, we report a 2-year-old girl with severe amitriptyline (70 mg/kg) intoxication. She was in comatose, had generalized tonic clonic seizure, ventricular tachycardia, and wide QRS complexes. Although she did not respond to classical therapies, very good clinical response to plasmapheresis was obtained and she developed no complications. Thus, plasmapheresis may be an effective treatment modality in poisoning with drugs, which bind to plasma proteins with high affinity. J. Clin. Apheresis, 2009. © 2009 Wiley-Liss, Inc.