Management of familial hypertriglyceridemia during pregnancy with plasma exchange

Authors

  • Praveen Sivakumaran,

    Corresponding author
    1. Division of Transfusion Medicine, Pathology and Lab Medicine, Cedars-Sinai Medical Center, Los Angeles, California
    • Division of Transfusion Medicine, Pathology and Lab Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Room 1680, Los Angeles, CA 90048
    Search for more papers by this author
  • Steven W. Tabak,

    1. Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California
    2. Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California
    Search for more papers by this author
  • Kimberly Gregory,

    1. Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California
    2. Department of Obstetrics and Gynecology, UCLA David Geffen School of Medicine and UCLA School of Public Health, Los Angeles, California
    Search for more papers by this author
  • Samuel H. Pepkowitz,

    1. Division of Transfusion Medicine, Pathology and Lab Medicine, Cedars-Sinai Medical Center, Los Angeles, California
    2. Department of Pathology, UCLA David Geffen School of Medicine, Los Angeles, California
    Search for more papers by this author
  • Ellen B. Klapper

    1. Division of Transfusion Medicine, Pathology and Lab Medicine, Cedars-Sinai Medical Center, Los Angeles, California
    2. Department of Pathology, UCLA David Geffen School of Medicine, Los Angeles, California
    Search for more papers by this author

Abstract

Hypertriglyceridemia-induced pancreatitis is a serious complication of familial dyslipidemias. Hormonal influences during pregnancy can compromise otherwise controlled lipid levels in women with familial hypertriglyceridemia and predispose to pancreatitis leading to increased morbidity in both mother and fetus. We report the successful use of therapeutic plasma exchange (TPE) in the management of hypertriglyceridemia during pregnancy resulting in avoidance of pancreatitis and delivery of a healthy term infant. Thirteen TPEs were performed from 19 to 36 weeks gestation to maintain tight control of triglyceride levels. J. Clin. Apheresis, 2009. © 2009 Wiley-Liss, Inc.

Ancillary