Successful therapeutic plasma exchange in a 3.2-kg body weight neonate with atypical hemolytic uremic syndrome
Article first published online: 14 FEB 2011
Copyright © 2011 Wiley-Liss, Inc.
Journal of Clinical Apheresis
Volume 26, Issue 3, pages 162–165, 2011
How to Cite
Jung, S., Kang, E.-S., Ki, C.-S., Kim, D.-W., Paik, K.-H. and Chang, Y. S. (2011), Successful therapeutic plasma exchange in a 3.2-kg body weight neonate with atypical hemolytic uremic syndrome. J. Clin. Apheresis, 26: 162–165. doi: 10.1002/jca.20283
- Issue published online: 6 JUN 2011
- Article first published online: 14 FEB 2011
- Manuscript Accepted: 25 DEC 2010
- Manuscript Received: 6 NOV 2010
- atypical hemolytic uremic syndrome;
- therapeutic plasma exchange;
- complement factor H
Atypical hemolytic uremic syndrome (aHUS) is a rare form of complement dysregulation disease, and recently various reports have shown that it is associated with one or more mutations in the complement regulatory genes including complement factor H (CFH). Plasma exchange is a therapeutic option for adult patients, but not for a very young infant because of a potential side effect of therapeutic plasma exchange (TPE) itself. Herein, we describe a case of successful treatment of early onset aHUS associated with a novel CFH mutation with total 21 sessions of TPE over a period of 46 days in 3.2 kg 23-day-old neonate. J. Clin. Apheresis, 2011. © 2011 Wiley-Liss, Inc.