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Commentary
Isovolemic hemodilution–red cell exchange for prevention of cerebrovascular accident in sickle cell anemia: The standard operating procedure
Article first published online: 2 FEB 2012
DOI: 10.1002/jca.21203
Copyright © 2012 Wiley Periodicals, Inc.
Additional Information
How to Cite
Matevosyan, K., Anderson, C. and Sarode, R. (2012), Isovolemic hemodilution–red cell exchange for prevention of cerebrovascular accident in sickle cell anemia: The standard operating procedure. J. Clin. Apheresis, 27: 88–92. doi: 10.1002/jca.21203
Publication History
- Issue published online: 10 APR 2012
- Article first published online: 2 FEB 2012
- Manuscript Accepted: 15 DEC 2011
- Manuscript Received: 21 JUL 2011
- Abstract
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- Cited By
Keywords:
- stroke prevention;
- COBE spectra;
- hemoglobin S;
- hematocrit;
- FCR
Abstract
Red blood cell exchange is an accepted superior therapy to simple chronic transfusion, due to minimal risk of iron overload, for secondary prevention of cerebrovascular accidents in selected patients with sickle cell anemia. Recently, we described our experience of Isovolemic Hemodilution–Red Blood Cell Exchange (IHD-RBCx), a two-step modification of the conventional RBCx with several advantages, including cost reduction. We are describing our standard operating procedure for IHD-RBCx with COBE Spectra apheresis system to make it widely available to the apheresis centers interested in implementing this procedure. J. Clin. Apheresis, 2012. © 2012 Wiley Periodicals, Inc.