These authors contributed equally to this work.
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Research Article
Predictive factors for inadequate stem cell mobilization in Chinese patients with NHL and HL: 14-year experience of a single-center study
Article first published online: 2 FEB 2012
DOI: 10.1002/jca.21204
Copyright © 2012 Wiley Periodicals, Inc.
Additional Information
How to Cite
Han, X., Ma, L., Zhao, L., He, X., Liu, P., Zhou, S., Yang, J., Qin, Y., Yang, S., Yao, J. and Shi, Y. (2012), Predictive factors for inadequate stem cell mobilization in Chinese patients with NHL and HL: 14-year experience of a single-center study. J. Clin. Apheresis, 27: 64–74. doi: 10.1002/jca.21204
Publication History
- Issue published online: 10 APR 2012
- Article first published online: 2 FEB 2012
- Manuscript Accepted: 7 DEC 2011
- Manuscript Received: 26 JUN 2011
Funded by
- National Natural Science Foundation of China. Grant Number: 30873012
- Ministry of Health Foundation for Distinguished Young. Grant Number: 9502054
- the Subject of the National Ninth Five-Year Plan. Grant Number: 96-906-01-12
- Ministry of Education Doctor Foundation. Grant Number: 20010023018, 20050023045, 20080023019
- Ministry of Health Foundation for Young College Teacher Foundation. Grant Number: B231996001
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Keywords:
- non-Hodgkin's lymphoma;
- Hodgkin's lymphoma;
- high-dose chemotherapy;
- autologous peripheral blood stem-cell transplant;
- mobilization
Abstract
Background: Factors affecting progenitor cell mobilization in patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) are incompletely understood. The aim of this retrospective study was to determine which factors are crucial for effective mobilization and collection of autologous peripheral blood stem cells (PBSC) prior to transplantation in Chinese patients. Patients and methods: A total of 239 patients with lymphoma (198 NHL and 41 HL patients) underwent PBSC collection after mobilization with granulocyte-colony-stimulating factor (G-CSF) or G-CSF plus chemotherapy priming. Results: Patient characteristics at diagnosis and transplant, including low Eastern Cooperative Oncology Group score (P = 0.013), lack of extranodal invasion (P = 0.034), previously administered radiotherapy regimens (P = 0.040), treatment with platinum prior to mobilization (P = 0.042), previous chemotherapy regimens (P = 0.001) and cycles (P < 0.001), and chemotherapy regimens (P < 0.001) were statistically significant for successful mobilization in multivariate analysis. Premobilization factors, including previous radiotherapy (P = 0.009), previous chemotherapy regimens (P = 0.043) and cycles (P = 0.039), low platelet count prior to mobilization (P = 0.042), and lower CD34+ cells in peripheral blood (PB) (P = 0.050) or bone marrow (BM) (P = 0.007) were considered possibly predictive of poor mobilization. We found the patients who had chemosensitive lymphoma had worse progress-free survival (PFS) than the patients with initial treatment and high risks (P = 0.017). Conclusion: Our analysis showed that high amounts of chemotherapy, radiotherapy, low platelet count, chemosensitive recurrent patients, combination chemotherapy plus G-CSF and low CD34+ cells in BM prior to mobilization could emerged as important predictive factors for mobilization failure in Chinese patients with NHL and HL. J. Clin. Apheresis, 2012. © 2012 Wiley Periodicals, Inc.