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Interleukin 17: An example for gene therapy as a tool to study cytokine mediated regulation of hematopoiesis

Authors

  • Paul Schwarzenberger,

    Corresponding author
    1. Gene Therapy Program, Louisiana State University Health Sciences Center of New Orleans, 533 Bolivar CRSB, New Orleans, Louisiana 70112
    • Gene Therapy Program, Louisiana State University Health Sciences Center of New Orleans, 533 Bolivar CRSB, New Orleans, LA 70112.
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  • Jay K. Kolls

    1. Gene Therapy Program, Louisiana State University Health Sciences Center of New Orleans, 533 Bolivar CRSB, New Orleans, Louisiana 70112
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Abstract

Interleukin 17 (IL-17) is an essential proinflammatory T-cell derived cytokine with various biological actions. IL-17 was found to have a pivotal role in microbial host defense by interconnecting lymphoid and myeloid host defense. It also acts as a stimulatory hematopoietic cytokine by expanding myeloid progenitors and initiating proliferation of mature neutrophils. This article summarizes results to date on IL-17 research and discusses gene therapy based strategies that were employed to determine its biological functions and significance. A comprehensive working model for IL-17 is introduced. J. Cell. Biochem. Suppl. 38: 88–95, 2002. © 2002 Wiley-Liss, Inc.

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