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Vitamin D regulation of the renin–angiotensin system
Article first published online: 7 NOV 2002
DOI: 10.1002/jcb.10343
Copyright © 2003 Wiley-Liss, Inc.
1097-4644/asset/cover.gif?v=1&s=c55ee036b3038496cb712d572571012ddd7c366c "Journal of Cellular Biochemistry")
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How to Cite
Li, Y. C. (2003), Vitamin D regulation of the renin–angiotensin system. Journal of Cellular Biochemistry, 88: 327–331. doi: 10.1002/jcb.10343
Publication History
- Issue published online: 6 JAN 2003
- Article first published online: 7 NOV 2002
- Manuscript Accepted: 2 AUG 2002
- Manuscript Received: 31 JUL 2002
Funded by
- NIH. Grant Numbers: DK59327, DK62072
- Abstract
- Article
- References
- Cited By
Keywords:
- vitamin D receptor;
- angiotensin II;
- blood pressure;
- hypertension
Abstract
The renin–angiotensin system (RAS) plays a central role in the regulation of blood pressure, electrolyte, and volume homeostasis. Epidemiological and clinical studies have long suggested an association of inadequate sunlight exposure or low serum 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] levels with high blood pressure and/or high plasma renin activity, but the mechanism is not understood. Our recent discovery that 1,25(OH)2D3 functions as a potent negative endocrine regulator of renin gene expression provides some insights into the mechanism. The concept of vitamin D regulation of blood pressure through the RAS opens a new avenue to our understanding of the physiological functions of the vitamin D endocrine system, and provides a basis for exploring the potential use of vitamin D analogues in prevention and treatment of hypertension. J. Cell. Biochem. 88: 327–331, 2003. © 2002 Wiley-Liss, Inc.