Proteins comprising the Rho family of GTPases mediate reorganization of the actin cytoskeleton as well as transcription of genes. Recent findings from genome sequencing efforts, genetic screens, and signal transduction research have revealed that the Rho family contains several new, hitherto unrecognized members. In this review, we focus on these newly discovered Rho-GTPases and discuss their role in signaling to the cytoskeleton and the nucleus. © 2004 Wiley-Liss, Inc.
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