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Mammalian Groucho homologs: Redundancy or specificity?

Authors

  • Malgorzata Gasperowicz,

    1. Department of Internal Medicine, Division of Haematology and Oncology, University of Freiburg Medical Centre, 79106 Freiburg, Germany
    2. Institute for Biology III, University of Freiburg, 79106 Freiburg, Germany
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  • Florian Otto

    Corresponding author
    1. Department of Internal Medicine, Division of Haematology and Oncology, University of Freiburg Medical Centre, 79106 Freiburg, Germany
    • Division of Haematology and Oncology, University of Freiburg Medical Centre, Hugstetterstr 55, D-79106 Freiburg, Germany.
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Abstract

The proteins termed TLE in humans, Grg in mice and Groucho in Drosophila constitute a family of transcriptional corepressors. In mammalians there are five different genes encoding an even larger number of proteins. Interactions between these TLE/Grg proteins and an array of transcription factors has been described. But is there any specificity? This review tries to make a case for a non-redundant function of individual TLE/Grg proteins. The specificity may be brought about by a tightly controlled temporo-spatial expression pattern, post-translational modifications, and subtle structural differences leading to distinct preferences for interacting transcription factors. A confirmation of this concept will ultimately need to come from genetic experiments. © 2005 Wiley-Liss, Inc.

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